Results 31 to 40 of about 356,160 (259)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Call Centers as Opportunities in Development of Less Developed Regions*
Megaron, 2009 At the end of the economic reconstruction process experienced since the 1980s, social scientists have discovered new industry areas, concepts such as flexible production and spatial division of labor, and they began focusing increasingly on services ...
Ayşe Nur ÖKTEN, Ebru SEÇKİN
doaj
Turkish Journal of Internal Medicine, 2021 Background and objective: Today, COVID-19 outbreak has become a global alert. So, lots of medical complications and socioeconomic and mental burdens have arisen following the outbreak of the disease.
Ehsan Amiri-ardekani +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Caderno de Administração, 2013 O setor de call center é um dos que mais empregam e crescem nos dias atuais. Embora seja de grande importância para a economia nacional, já que emprega um grande número de pessoas, não se pode desconsiderar que o avanço do setor não ocorreu da mesma ...
Fabiele Cândido de Almeida +1 more
doaj
Voice Transmission Over JP Networks
Promet (Zagreb), 2004 Voice transmission over JP networks (Voice over InternetProtocol) represents one of the ways in which voice and datanetworks are integrated. The future development is based onthe explosion of the Internet as the means of communication,with the openness ...
Slavko Šarić, Anto Bilobrk, Davor Nađ
doaj +1 more source