Caloric restriction and its mimetics [PDF]
BMB Reports, 2013 Caloric restriction is the most reliable intervention to preventage-related disorders and extend lifespan. The reduction ofcalories by 10-30% compared to an ad libitum diet is known toextend the longevity of various species from yeast to rodents.The ...
Shin-Hae Lee, Kyung-Jin Min
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Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms [PDF]
Nature CommunicationsCaloric restriction prolongs lifespan and preserves health across species, with feeding times synchronized to day–night cycles further maximizing benefits. However, the mechanisms linking diet, diurnal rhythms, and lifespan remain unclear.
Konstantinos Makris +14 more
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Caloric restriction delays age-related methylation drift
Nature Communications, 2017 Caloric restriction has been shown to increase lifespan in mammals. Here, the authors provide evidence that age-related methylation drift correlates with lifespan and that caloric restriction in mice and rhesus monkeys results in attenuation of age ...
Shinji Maegawa +8 more
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Biomedicines, 2020 Caloric restriction (CR) represents a powerful intervention for extending healthspan and lifespan in several animal models, from yeast to primates. Additionally, in humans, CR has been found to induce cardiometabolic adaptations associated with improved ...
Daniele La Russa +4 more
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Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment [PDF]
MetabolitesCaloric restriction (CR) and its related alternatives have been shown to be the only interventions capable of extending lifespan and decreasing the risk of cancer, along with a reduction in burden in pre-clinical trials.
Ulises Edgardo De-Leon-Covarrubias +8 more
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Effect of 8 weeks high-intensity interval training (HIIT) with and without caloric restriction on gene expression of myocardial Bax and Bcl2 in mice [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021 Background: Apoptosis is the physiological cell death that in natural conditions leads to the elimination of old, damaged, waste, and harmful cells. The aim of this study was the effect of eight weeks of high-intensity interval training (HIIT) with and ...
Mohammadreza Zarali +3 more
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The effect of eight weeks of high-intensity interval training with caloric restriction and spirulina supplementation on inflammatory factors in heart tissue of rats under high-fat diet [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2023 Background and Purpose: The increase of inflammatory factors following obesity is known as one of the main causes of mortality. Although the role of exercise training, caloric restriction and antioxidant supplements have been reported in this field; But ...
Jamshid Khirabadi +3 more
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Beneficial effects of intermittent fasting: a narrative review [PDF]
Journal of Yeungnam Medical Science, 2023 Caloric restriction is a popular approach to treat obesity and its associated chronic illnesses but is difficult to maintain for a long time. Intermittent fasting is an alternative and easily applicable dietary intervention for caloric restriction ...
Dae-Kyu Song, Yong-Woon Kim
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Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
Science, 2022 Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22-hour fasting, raising the question of if it is calories, fasting, or time of ...
V. Acosta-Rodríguez +6 more
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Nature Aging, 2023 The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1–3.
R. Waziry +21 more
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