Results 11 to 20 of about 417,246 (251)

Caloric restriction delays age-related methylation drift

Nature Communications, 2017
Caloric restriction has been shown to increase lifespan in mammals. Here, the authors provide evidence that age-related methylation drift correlates with lifespan and that caloric restriction in mice and rhesus monkeys results in attenuation of age ...
Shinji Maegawa, Yue Lu, Tomomitsu Tahara, Justin T. Lee, Jozef Madzo, Shoudan Liang, Jaroslav Jelinek, Ricki J. Colman, Jean-Pierre J. Issa   +8 more
doaj   +2 more sources

Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved]

F1000Research, 2016
Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates.
Changhan Lee, Valter Longo
doaj   +2 more sources

Epigenetic regulation of caloric restriction in aging

BMC Medicine, 2011
The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans.
Daniel Michael, Li Yuanyuan, Tollefsbol Trygve O   +2 more
doaj   +2 more sources

Effect of Dietary Restriction on Muscle Performance in Drosophila [PDF]

, 2011
Dietary restriction (DR) can extend the lifespan in various organisms and is thought to present potential benefits in human. However, it is still a controversial issue now among scientists due to lack of strong supportive evidence in human.
Hsu, Pin-Chia
core   +6 more sources

Metabolic and behavioral compensations in response to caloric restriction: Implications for the maintenance of weight loss [PDF]

, 2009
BackgroundMetabolic and behavioral adaptations to caloric restriction (CR) in free-living conditions have not yet been objectively measured.Methodology and principal findingsForty-eight (36.8+/-1.0 y), overweight (BMI 27.8+/-0.7 kg/m(2)) participants ...
Eric Ravussin, Ravussin, E., Corby K. Martin, Leanne M Redman, Heilbronn, L., Corby K Martin, James P. Delany, Lilian de Jonge, Leonie K Heilbronn, Donald A Williamson, James P Delany, de Jonge, L., DeLany, J., Redman, L., Leanne M. Redman, null null, Martin, C., Pennington CALERIE Team, Williamson, D., Leonie K. Heilbronn, Donald A. Williamson   +20 more
core   +2 more sources

Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster [PDF]

, 2009
Background: Outcomes of lifespan studies in model organisms are particularly susceptible to variations in technical procedures. This is especially true of dietary restriction, which is implemented in many different ways among laboratories.
Linda Partridge, Partridge, L., Wong, Richard, Timothy M Bass, Partridge Linda, Grandison, R.C., Richard Wong, Wong, R., Tanimoto, H., Richard C Grandison, Bass, TM, Matthew D W Piper, Piper, M.D.W., Grandison, RC, Grandison, Richard C., Partridge, Linda, Wong, R, Bass Timothy M., Piper, MDW, Piper Matthew D. W., Partridge, L, Grandison Richard C., Bass, Timothy M., Piper, M. D W, Wong Richard, Bass, T.M.   +25 more
core   +2 more sources

Standardizing caloric restriction for preclinical cancer research. [PDF]

Biotechniques
Despite increasing rates of metabolic syndrome, cancer treatment regimens often ignore the underlying metabolic dysfunction in patients. A high proportion of cancer patients have metabolic dysfunction, and caloric restriction has shown the potential to ...
Jacoby JL, Calderon Aparicio A, François NB, Thapar M, Burke SE, Xu S, DeAngelis T, Shastri A, Tran PT, Simone NL.   +9 more
europepmc   +2 more sources

Colon tumor promotion, is it a selection process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts [PDF]

, 1997
Promotion would suppose the selection of initiated cells. We tested the selection of aberrant crypt cells by cholic acid, a colon cancer promoter, and the effect of protectors, phytate and food restriction.
Peiffer, Ginette, Denis E. Corpet, Sylviane Taché, Taché, Sylviane, Ginette Peiffer, Corpet, Denis E.   +5 more
core   +1 more source

The effect of complete caloric intake restriction on human body odour quality [PDF]

, 2019
Previous studies on various vertebrates have shown that quantity and quality of food intake affect odour attractiveness as perceived by potential mates. In humans, the quality of body odour is similarly affected by ingested foods, such as by variation in
Fialová, Jitka, Havlíček, Jan, Hoffmann, Rudolf, Roberts, S Craig   +3 more
core   +1 more source

AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice

Molecular Pain, 2017
Background Caloric restriction is associated with broad therapeutic potential in various diseases and an increase in health and life span. In this study, we assessed the impact of caloric restriction on acute and inflammatory nociception in mice, which ...
Tanya S King-Himmelreich, Christine V Möser, Miriam C Wolters, Julia Schmetzer, Moritz Möller, Yannik Schreiber, Nerea Ferreirós, Gerd Geisslinger, Ellen Niederberger   +8 more
doaj   +1 more source