Results 21 to 30 of about 43,531 (265)

Caloric Restriction and Antiaging Effects [PDF]

Annals of Nutrition and Metabolism, 2011
Caloric restriction (CR) is widely used to study aging processes. It is a simple and highly reproducible method for delaying the aging process, preventing the onset of aging-related diseases and extending average or maximum lifespan. However, the mechanism underlying these effects of CR is still not clear.
Lan, Xiang, Guoqing, He
openaire   +2 more sources

Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice

Journal of Aging Research, 2014
Aging associated changes in liver include reduced hepatic blood flow, increased number of stellate cells, and collagen deposits in perisinusoidal space. We tested the possibility of mitigating these changes with caloric restriction.
Jian Chen, Kara King, Jian X. Zhang
doaj   +1 more source

Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa [PDF]

Current Opinion in Clinical Nutrition and Metabolic Care, 2013
To examine the role of two nutritional factors implicated in the healthy aging of the Okinawans: caloric restriction; and traditional foods with potential caloric restriction-mimetic properties.Caloric restriction is a research priority for the US National Institute on Aging. However, little is known regarding health effects in humans.
Bradley J, Willcox, Donald C, Willcox
openaire   +2 more sources

Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice

Nature Communications, 2022
Caloric restriction is a common approach to weight reduction, however, weight regain is common. Here the authors report that caloric restriction reduces the abundance of Parabacteroides distasonis in the gut and alters serum bile acid (BA) profile, which
Mengci Li, Shouli Wang, Yitao Li, Mingliang Zhao, Junliang Kuang, Dandan Liang, Jieyi Wang, Meilin Wei, Cynthia Rajani, Xinran Ma, Yajun Tang, Zhenxing Ren, Tianlu Chen, Aihua Zhao, Cheng Hu, Chengxing Shen, Weiping Jia, Ping Liu, Xiaojiao Zheng, Wei Jia   +19 more
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Caloric restriction and genomic stability [PDF]

Nucleic Acids Research, 2007
Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced tumors in laboratory rodents while increasing mean and maximum life spans. It has been suggested that CR extends longevity and reduces age-related pathologies by reducing the levels of DNA damage and mutations that accumulate with age.
Heydari, Ahmad R., Unnikrishnan, Archana, Lucente, Lisa Ventrella, Richardson, Arlan   +3 more
openaire   +2 more sources

Caloric restriction suppresses exercise-induced hippocampal BDNF expression in young male rats

Journal of Physical Fitness and Sports Medicine, 2018
Both exercise training and chronic caloric restriction contribute to brain health through enhanced expression of brain-derived neurotrophic factor (BDNF). This study investigated the synergistic effects between 12-week low-intensity exercise training and
Shohei Dobashi, Chinatsu Aiba, Daisuke Ando, Masataka Kiuchi, Mitsuya Yamakita, Katsuhiro Koyama   +5 more
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3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB

EMBO Molecular Medicine, 2019
Caloric restriction mimetics (CRMs) are natural or synthetic compounds that mimic the health‐promoting and longevity‐extending effects of caloric restriction.
Guo Chen, Wei Xie, Jihoon Nah, Allan Sauvat, Peng Liu, Federico Pietrocola, Valentina Sica, Didac Carmona‐Gutierrez, Andreas Zimmermann, Tobias Pendl, Jelena Tadic, Martina Bergmann, Sebastian J Hofer, Lana Domuz, Sylvie Lachkar, Maria Markaki, Nektarios Tavernarakis, Junichi Sadoshima, Frank Madeo, Oliver Kepp, Guido Kroemer   +20 more
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Effects of maternal nutrient restriction during the periconceptional period on placental development in the mouse.

PLoS ONE, 2021
Maternal undernutrition has detrimental effects on fetal development and adult health. Total caloric restriction during early pregnancy followed by adequate nutrition for the remainder of gestation, is particularly linked to cardiovascular and metabolic ...
Gerialisa Van Gronigen Case, Kathryn M Storey, Lauren E Parmeley, Laura C Schulz   +3 more
doaj   +1 more source

Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats. [PDF]

PLoS ONE, 2017
Studies have demonstrated that resveratrol (a natural polyphenol) and caloric restriction activate Sirtuin-1 (SIRT1) and induce autophagy. Furthermore, autophagy is induced by the SIRT1-FoxO signaling pathway and was recently shown to be a critical ...
Shibin Ding, Jinjin Jiang, Guofu Zhang, Yongjun Bu, Guanghui Zhang, Xiangmei Zhao   +5 more
doaj   +1 more source

Chronic Caloric Restriction and Exercise Improve Metabolic Conditions of Dietary-Induced Obese Mice in Autophagy Correlated Manner without Involving AMPK

Journal of Diabetes Research, 2013
Aim. To investigate the role of AMPK activation and autophagy in mediating the beneficial effects of exercise and caloric restriction in obesity. Methods.
Mingxia Cui, Han Yu, Jinli Wang, Junjie Gao, Ji Li   +4 more
doaj   +1 more source