Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment [PDF]
MetabolitesCaloric restriction (CR) and its related alternatives have been shown to be the only interventions capable of extending lifespan and decreasing the risk of cancer, along with a reduction in burden in pre-clinical trials.
Roberto Montes-de-Oca-Luna +2 more
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Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics [PDF]
Frontiers in Nutrition, 2021 The average human life expectancy continues to rise globally and so does the prevalence and absolute burden of cardiovascular disease. Dietary restriction promotes longevity and improves various cardiovascular risk factors, including hypertension ...
Julia Voglhuber +8 more
doaj +4 more sources
Caloric restriction and its mimetics [PDF]
BMB Reports, 2013 Caloric restriction is the most reliable intervention to preventage-related disorders and extend lifespan. The reduction ofcalories by 10-30% compared to an ad libitum diet is known toextend the longevity of various species from yeast to rodents.The ...
Kyung-Jin Min
exaly +4 more sources
Caloric restriction mimetics chlorogenic acid and fisetin as potential autophagy inducers targeting ATG101 [PDF]
Biochemistry and Biophysics ReportsAutophagy is an important cytoprotective process impaired in neurodegenerative diseases such as Alzheimer's disease. The initiation process is mediated by the protein kinase Unc-51-like kinase 1 (ULK1) complex.
Apoorv Sharma +5 more
doaj +3 more sources
A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice [PDF]
OncoImmunology, 2019 We have recently shown that chemotherapy with immunogenic cell death (ICD)-inducing agents can be advantageously combined with fasting regimens or caloric restriction mimetics (CRMs) to achieve superior tumor growth control via a T cell-dependent ...
Juliette Paillet +2 more
exaly +3 more sources
Caloric Restriction Mimetics in Nutrition and Clinical Trials [PDF]
Frontiers in Nutrition, 2021 The human diet and dietary patterns are closely linked to the health status. High-calorie Western-style diets have increasingly come under scrutiny as their caloric load and composition contribute to the development of non-communicable diseases, such as ...
Sebastian J. Hofer +8 more
doaj +2 more sources
The Roles of Caloric Restriction Mimetics in Central Nervous System Demyelination and Remyelination [PDF]
Current Issues in Molecular Biology, 2023 The dysfunction of myelinating glial cells, the oligodendrocytes, within the central nervous system (CNS) can result in the disruption of myelin, the lipid-rich multi-layered membrane structure that surrounds most vertebrate axons.
Despoina Kaffe +2 more
doaj +2 more sources
Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences [PDF]
Military Medical Research, 2022 The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD).
Lei Pang +8 more
doaj +2 more sources
Caloric Restriction Mimetics as Priming Agents of Mesenchymal Stem Cells Secretome to Enhance Regenerative Responses to Parkinson’s Disease [PDF]
MoleculesParkinson’s disease (PD) is a neurodegenerative disorder primarily defined by the deterioration of motor function and characterized by the loss of dopaminergic neurons in the nigrostriatal system.
Bárbara Carneiro-Pereira +4 more
doaj +2 more sources
Local Administration of Caloric Restriction Mimetics to Promote the Immune Control of Lung Metastases [PDF]
Journal of Immunology Research, 2019 Caloric restriction mimetics (CRMs), compounds that mimic the biochemical effects of nutrient deprivation, administered via systemic route promote antitumor effects through the induction of autophagy and the modulation of the immune microenvironment ...
Valentino Le Noci +6 more
doaj +2 more sources