Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer Immunotherapy [PDF]
Cancers, 2021 International audienceCaloric restriction and fasting have been known for a long time for their health- and life-span promoting effects, with coherent observations in multiple model organisms as well as epidemiological and clinical studies.
Juliette Paillet +2 more
exaly +3 more sources
Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan [PDF]
International Journal of Molecular Sciences, 2020 Caloric restriction (CR), the reduction of caloric intake without inducing malnutrition, is the most reproducible method of extending health and lifespan across numerous organisms, including humans.
Darrell D Mousseau +2 more
exaly +3 more sources
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance [PDF]
Cancer Cell, 2016 International audienceCaloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins, thus triggering autophagy.
Norma Bloy +2 more
exaly +3 more sources
Frontiers in Genetics, 2016 Caloric restriction (CR), defined as decreased nutrient intake without causing malnutrition, has been documented to increase both health and lifespan across numerous organisms, including humans.
Zoe E. Gillespie +3 more
doaj +2 more sources
Cardiovascular DiabetologyThe global increase in human life expectancy, coupled with an unprecedented rise in the prevalence of obesity, has led to a growing clinical and socioeconomic burden of heart failure with preserved ejection fraction (HFpEF).
Alexander Fuerlinger +3 more
doaj +2 more sources
Caloric Restriction Mimetic Hydroxycitrate Mitigates Acute Nephrotoxicity via Autophagy Activation and Oxidative Stress Reduction [PDF]
BiomoleculesDrug-induced nephrotoxicity is a leading cause of acute kidney injury (AKI) and subsequent chronic kidney disease. Nephrotoxicity often develops as a consequence of treatment with commonly prescribed aminoglycoside antibiotics, and remains a significant ...
Xinyu Liao +11 more
doaj +2 more sources
Astrocytes as Perspective Targets of Exercise- and Caloric Restriction-Mimetics. [PDF]
Neurochem Res, 2021 Enhanced mental and physical activity can have positive effects on the function of aging brain, both in the experimental animals and human patients, although cellular mechanisms underlying these effects are currently unclear.
Lalo U, Pankratov Y.
europepmc +2 more sources
Caloric restriction promotes the stemness and antitumor activity of T lymphocytes
OncoImmunology, 2019 Recent findings have shed new light on the mechanisms through which tumor-infiltrating lymphocytes (TILs) maintain their cytotoxic potential in the context of checkpoint blockade or adoptive transfer therapies.
Federico Pietrocola, Guido Kroemer
doaj +2 more sources
PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons. [PDF]
Aging (Albany NY), 2021 Caloric restriction has been shown to robustly ameliorate age-related diseases and to prolong lifespan in several model organisms, and these beneficial effects are dependent on the stimulation of autophagy.
Ferreira-Marques M +3 more
europepmc +2 more sources
Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research [PDF]
Nutrients, 2020 Alexander Gulyayev +2 more
exaly +2 more sources