Results 21 to 30 of about 384,773 (212)
Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers [PDF]
Autophagy, 2014 Federico Pietrocola +2 more
exaly +2 more sources
Caloric restriction mimetics as a therapeutic approach to metabolic syndrome [PDF]
, 2023 Caloric restriction is a reduction in caloric intake without reaching a state of malnutrition, and it affects multiple cellular signaling pathways. Experimental data shows that this leads to an increase in longevity or in maintaining a healthy state for ...
Valcheva-Kuzmanova, Stefka; Medical University of Varna +1 more
core +1 more source
The Discovery of Druggable Anti-aging Agents [PDF]
Annals of Geriatric Medicine and Research, 2020 Caloric restriction (CR) has been shown to extend the lifespan of many species. Research to identify compounds that imitate the results of CR has shown extensions of both lifespan and healthspan via different mechanisms.
Gulperi Yalcin, Cheol-Koo Lee
doaj +1 more source
NOT JUST CALORIC RESTRICTION: A COMPLEX APPROACH TO PROLONG LIFESPAN AND IMPROVE QUALITY OF LIFE
Central Asian Journal of Medical Hypotheses and Ethics, 2021 Aging is an urgent healthcare issue in view of the rapid growth of the proportion of older persons. Searching for reliable aging biomarkers and prolonging lifespan are increasingly important scientific directions.
Galina V. Morgunova
doaj +1 more source
Effect of Dietary Restriction on Muscle Performance in Drosophila [PDF]
, 2011 Dietary restriction (DR) can extend the lifespan in various organisms and is thought to present potential benefits in human. However, it is still a controversial issue now among scientists due to lack of strong supportive evidence in human.
Hsu, Pin-Chia
core +6 more sources
Mechanisms and Effects of Dietary Restriction on CNS and Affective Disorders
Acta Medica Bulgarica, 2020 Neuropsychiatric disorders, including depression contribute significantly to global disability and possess high social and health burden. Management is dominated by pharmacotherapy and psychotherapy; nevertheless, such treatments prevent or treat less ...
Haritov E. +4 more
doaj +1 more source
Frontiers in Aging, 2023 In the last decades, important progress has been achieved in the understanding of the neurotrophic effects of intermittent fasting (IF), calorie restriction (CR) and exercise.
Eric Mayor
doaj +1 more source
Caloric restriction and exercise "mimetics'': Ready for prime time? [PDF]
, 2015 Exercise and diet are powerful interventions to prevent and ameliorate various pathologies. The development of pharmacological agents that confer exercise- or caloric restriction-like phenotypic effects is thus an appealing therapeutic strategy in ...
Handschin, Christoph
core +1 more source
Tolerance to NADH/NAD+ imbalance anticipates aging and anti-aging interventions
iScience, 2021 Summary: Redox couples coordinate cellular function, but the consequences of their imbalances are unclear. This is somewhat associated with the limitations of their experimental quantification.
Alvar J. Alonso-Lavin +2 more
doaj +1 more source
Plant and fungal products that extend lifespan in Caenorhabditis elegans
Microbial Cell, 2020 The nematode Caenorhabditis elegans is a useful model to study aging due to its short lifespan, ease of manipulation, and available genetic tools. Several molecules and extracts derived from plants and fungi extend the lifespan of C.
Jan Martel +6 more
doaj +1 more source