Results 211 to 220 of about 42,379 (263)
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Molecular Aspects of Medicine, 2011
Restricting the intake of calories has been practiced as a method for increasing both the length and quality of life for over 500 years. Experimental work confirming the success of this approach in animals has accumulated over the last 100 years. Lifelong caloric restriction (CR) may extend life by up to 50% in rodents, with progressively less impact ...
John R, Speakman, Sharon E, Mitchell
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Restricting the intake of calories has been practiced as a method for increasing both the length and quality of life for over 500 years. Experimental work confirming the success of this approach in animals has accumulated over the last 100 years. Lifelong caloric restriction (CR) may extend life by up to 50% in rodents, with progressively less impact ...
John R, Speakman, Sharon E, Mitchell
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Caloric Restriction in Primates
Annals of the New York Academy of Sciences, 2001Abstract:Caloric restriction (CR) remains the only nongenetic intervention that reproducibly extends mean and maximal life span in short‐lived mammalian species. This nutritional intervention also delays the onset, or slows the progression, of many age‐related disease processes. The diverse effects of CR have been demonstrated many hundreds of times in
M A, Lane +5 more
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Science Signaling, 2009
A signaling pathway in mice mediates the effects of caloric restriction that protect against age-related diseases.
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A signaling pathway in mice mediates the effects of caloric restriction that protect against age-related diseases.
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Proteolysis, caloric restriction and aging
Mechanisms of Ageing and Development, 2001The nature of the aging process has been the subject of considerable speculation. It is believed that free radical damage to cellular components is one of the main contributors to the aging process. Studies on proteins have shown age-related decline in enzyme activities, age-related accumulation of oxidized proteins and a decline of the proteolytic ...
K, Merker, A, Stolzing, T, Grune
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Science's STKE, 2003
Restricting calories extends the life-span of various organisms. In the yeast Saccharomyces cerevisiae , this depends upon increased activity of Sir2, a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase.
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Restricting calories extends the life-span of various organisms. In the yeast Saccharomyces cerevisiae , this depends upon increased activity of Sir2, a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase.
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Slowing ageing by caloric restriction
Nature Medicine, 1995Dietary caloric restriction is the only intervention conclusively shown to slow ageing, delay the onset of age-related diseases, maintain function and extend both median and maximal life span in mammals.
G S, Roth, D K, Ingram, M A, Lane
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2007
Caloric restriction remains the only nongenetic intervention that has been consistently and reproducibly shown to extend both average and maximal lifespan in a wide variety of species. If shown to be applicable to human aging, it is unlikely that most people would be able to maintain the 30-40% reduction in food intake apparently required for this ...
Mark A. Lane +2 more
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Caloric restriction remains the only nongenetic intervention that has been consistently and reproducibly shown to extend both average and maximal lifespan in a wide variety of species. If shown to be applicable to human aging, it is unlikely that most people would be able to maintain the 30-40% reduction in food intake apparently required for this ...
Mark A. Lane +2 more
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Caloric restriction and brain function
Current Opinion in Clinical Nutrition and Metabolic Care, 2008In addition to extending lifespan, animal research shows that specific diets benefit brain functioning. Indeed, it has been proven that caloric restriction prevents age-related neuronal damage. What are those mechanisms involved in the effects of caloric restriction on brain functioning? Could caloric restriction be proposed in the future to prevent or
Sophie, Gillette-Guyonnet, Bruno, Vellas
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Science of Aging Knowledge Environment, 2003
Caloric (or dietary) restriction (CR) is the most potent, robust, and reproducible known means of extending longevity and decreasing morbidity in laboratory mammals. Two of the major questions faced by researchers in this field are the applicability to humans and the biochemical mechanism(s) involved in the actions of CR.
Bruce S, Kristal, Ugo, Paolucci
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Caloric (or dietary) restriction (CR) is the most potent, robust, and reproducible known means of extending longevity and decreasing morbidity in laboratory mammals. Two of the major questions faced by researchers in this field are the applicability to humans and the biochemical mechanism(s) involved in the actions of CR.
Bruce S, Kristal, Ugo, Paolucci
openaire +2 more sources