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Overview of caloric restriction and ageing
Mechanisms of Ageing and Development, 2005It has been known for some 70 years that restricting the food intake of laboratory rats extends their mean and maximum life span. In addition, such life extension has been observed over the years in many other species, including mice, hamsters, dogs, fish, invertebrate animals, and yeast.
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Nutrigenetics and Nutrigenomics of Caloric Restriction
2012Obesity is a complex disease resulting from a chronic and long-term positive energy balance in which both genetic and environmental factors are involved. Weight-reduction methods are mainly focused on dietary changes and increased physical activity. However, responses to nutritional intervention programs show a wide range of interindividual variation ...
Itziar, Abete +3 more
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Science of Aging Knowledge Environment, 2003
Caloric (or dietary) restriction (CR) is the most potent, robust, and reproducible known means of extending longevity and decreasing morbidity in laboratory mammals. Two of the major questions faced by researchers in this field are the applicability to humans and the biochemical mechanism(s) involved in the actions of CR.
Bruce S, Kristal, Ugo, Paolucci
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Caloric (or dietary) restriction (CR) is the most potent, robust, and reproducible known means of extending longevity and decreasing morbidity in laboratory mammals. Two of the major questions faced by researchers in this field are the applicability to humans and the biochemical mechanism(s) involved in the actions of CR.
Bruce S, Kristal, Ugo, Paolucci
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An in vitro model of caloric restriction
Experimental Gerontology, 2003The mechanisms underlying the ability of caloric restriction (CR) to extend life span and enhance stress responsiveness remain elusive. Progress in this area has been slow due to the complexities of using animals for CR studies and assessing life span as the measure of CR effectiveness. It is therefore of great interest to develop in vitro models of CR.
Rafael, de Cabo +5 more
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Caloric Restriction and Longevity
Annals of the New York Academy of Sciences, 2009Aging involves a gradual increase in disorder of the systems that sustain living. Although stress is a major driver of this process, one stressor, caloric restriction (CR), is the only intervention proven to extend life span in multiple species as well as extend the persistence of those characteristics that are associated with youth.
Linda Hotchkiss, Mehta, George S, Roth
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Caloric restriction and aging: an update
Experimental Gerontology, 2000Restricting food intake to 50 to 70% of that eaten by ad lib-fed rats and mice markedly increases longevity, retards age-associated physiological deterioration, and delays and, in some cases, prevents age-associated diseases. These actions are due to the reduced intake of calories, and thus the phenomenon has been called the antiaging action of caloric
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Scientific American sp, 1996
The relationship between eating less and greater longevity is explored. The author notes that eating less but ensuring an adequate supply of protein fat vitamins and minerals has been shown to improve the health and longevity of rodents. The relevance of these findings to humans is considered. (ANNOTATION)
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The relationship between eating less and greater longevity is explored. The author notes that eating less but ensuring an adequate supply of protein fat vitamins and minerals has been shown to improve the health and longevity of rodents. The relevance of these findings to humans is considered. (ANNOTATION)
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Science Signaling, 2003
Restricting calories extends the life-span of various organisms. In the yeast Saccharomyces cerevisiae , this depends upon increased activity of Sir2, a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase.
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Restricting calories extends the life-span of various organisms. In the yeast Saccharomyces cerevisiae , this depends upon increased activity of Sir2, a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase.
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Caloric Restriction, Gene Expression, and Aging
Alzheimer Disease & Associated Disorders, 2003Abstract Caloric restriction (CR) increases maximum life span in many species. In laboratory rodents, CR started either early in life or in middle-age opposes the development of age-associated biological and pathological changes. Three main questions are being asked by CR investigators. How does CR retard aging and disease processes?
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