Results 211 to 220 of about 43,531 (265)
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Molecular Aspects of Medicine, 2011
Restricting the intake of calories has been practiced as a method for increasing both the length and quality of life for over 500 years. Experimental work confirming the success of this approach in animals has accumulated over the last 100 years. Lifelong caloric restriction (CR) may extend life by up to 50% in rodents, with progressively less impact ...
John R, Speakman, Sharon E, Mitchell
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Restricting the intake of calories has been practiced as a method for increasing both the length and quality of life for over 500 years. Experimental work confirming the success of this approach in animals has accumulated over the last 100 years. Lifelong caloric restriction (CR) may extend life by up to 50% in rodents, with progressively less impact ...
John R, Speakman, Sharon E, Mitchell
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Caloric Restriction in Primates
Annals of the New York Academy of Sciences, 2001Abstract:Caloric restriction (CR) remains the only nongenetic intervention that reproducibly extends mean and maximal life span in short‐lived mammalian species. This nutritional intervention also delays the onset, or slows the progression, of many age‐related disease processes. The diverse effects of CR have been demonstrated many hundreds of times in
M A, Lane +5 more
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Caloric Restriction and Toxicity
Fundamental and Applied Toxicology, 1995The modulatory effects of caloric intake on the rate and extent of both spontaneous and induced disease incidence is well known, but the significance of these effects in the interpretation of testing data has only recently become appreciated. This is especially true relative to the impact of caloric intake on both survival and background incidence for ...
R W, Hart +5 more
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Proteolysis, caloric restriction and aging
Mechanisms of Ageing and Development, 2001The nature of the aging process has been the subject of considerable speculation. It is believed that free radical damage to cellular components is one of the main contributors to the aging process. Studies on proteins have shown age-related decline in enzyme activities, age-related accumulation of oxidized proteins and a decline of the proteolytic ...
K, Merker, A, Stolzing, T, Grune
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Slowing ageing by caloric restriction
Nature Medicine, 1995Dietary caloric restriction is the only intervention conclusively shown to slow ageing, delay the onset of age-related diseases, maintain function and extend both median and maximal life span in mammals.
G S, Roth, D K, Ingram, M A, Lane
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Caloric Restriction and Caloric Restriction Mimetics: Current Status and Promise for the Future
Journal of the American Geriatrics Society, 2005Dietary caloric restriction is the most reproducible means of extending longevity and maintaining health and vitality. It has been shown to be relevant to a wide rage of species, including primates. Examination of key markers of the calorically restricted phenotype, such as plasma insulin, dehydroepiandrosterone sulfate, and body temperature, suggest ...
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Caloric restriction and brain function
Current Opinion in Clinical Nutrition and Metabolic Care, 2008In addition to extending lifespan, animal research shows that specific diets benefit brain functioning. Indeed, it has been proven that caloric restriction prevents age-related neuronal damage. What are those mechanisms involved in the effects of caloric restriction on brain functioning? Could caloric restriction be proposed in the future to prevent or
Sophie, Gillette-Guyonnet, Bruno, Vellas
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