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Caloric Restriction and Antiaging Effects [PDF]
Annals of Nutrition and Metabolism, 2011 Caloric restriction (CR) is widely used to study aging processes. It is a simple and highly reproducible method for delaying the aging process, preventing the onset of aging-related diseases and extending average or maximum lifespan. However, the mechanism underlying these effects of CR is still not clear.
Lan, Xiang, Guoqing, He
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Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice
Journal of Aging Research, 2014 Aging associated changes in liver include reduced hepatic blood flow, increased number of stellate cells, and collagen deposits in perisinusoidal space. We tested the possibility of mitigating these changes with caloric restriction.
Jian Chen, Kara King, Jian X. Zhang
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Caloric restriction and genomic stability [PDF]
Nucleic Acids Research, 2007 Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced tumors in laboratory rodents while increasing mean and maximum life spans. It has been suggested that CR extends longevity and reduces age-related pathologies by reducing the levels of DNA damage and mutations that accumulate with age.
Heydari, Ahmad R. +3 more
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Aspirin—another caloric-restriction mimetic [PDF]
Autophagy, 2018 The capacity of cells and organisms to sustain, and to eventually adapt to, environmental and genetic insults declines with age. Because macroautophagy/autophagy is regarded as one of the major determinants of cellular fitness in vitro and in vivo, maneuvers that aim at promoting autophagy may slow down aging and promote health span.
Federico Pietrocola +3 more
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Nature Communications, 2022 Caloric restriction is a common approach to weight reduction, however, weight regain is common. Here the authors report that caloric restriction reduces the abundance of Parabacteroides distasonis in the gut and alters serum bile acid (BA) profile, which
Mengci Li +19 more
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Caloric restriction suppresses exercise-induced hippocampal BDNF expression in young male rats
Journal of Physical Fitness and Sports Medicine, 2018 Both exercise training and chronic caloric restriction contribute to brain health through enhanced expression of brain-derived neurotrophic factor (BDNF). This study investigated the synergistic effects between 12-week low-intensity exercise training and
Shohei Dobashi +5 more
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Caloric restriction and cellular senescence [PDF]
Mechanisms of Ageing and Development, 2018 Cellular senescence is a state of irreversible growth arrest characterized by hypertrophy and secretion of various bioactive molecules, a phenomenon defined the Senescence-Associated Secretory Phenotype (SASP). Senescent cells are implicated in a number of biological functions, from embryogenesis to aging.
Luigi Fontana +2 more
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EMBO Molecular Medicine, 2019 Caloric restriction mimetics (CRMs) are natural or synthetic compounds that mimic the health‐promoting and longevity‐extending effects of caloric restriction.
Guo Chen +20 more
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PLoS ONE, 2021 Maternal undernutrition has detrimental effects on fetal development and adult health. Total caloric restriction during early pregnancy followed by adequate nutrition for the remainder of gestation, is particularly linked to cardiovascular and metabolic ...
Gerialisa Van Gronigen Case +3 more
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Journal of Diabetes Research, 2013 Aim. To investigate the role of AMPK activation and autophagy in mediating the beneficial effects of exercise and caloric restriction in obesity. Methods.
Mingxia Cui +4 more
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