Results 31 to 40 of about 844,015 (339)

Caloric Restriction Mitigates Kidney Fibrosis in an Aged and Obese Rat Model

Antioxidants, 2023
Caloric restriction is an effective intervention to protract healthspan and lifespan in several animal models from yeast to primates, including humans.
Daniele La Russa, Laura Barberio, Alessandro Marrone, Anna Perri, Daniela Pellegrino   +4 more
doaj   +1 more source

Contribution of PGC-1α to Obesity- and Caloric Restriction-Related Physiological Changes in White Adipose Tissue

International Journal of Molecular Sciences, 2021
Peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α) regulates mitochondrial DNA replication and mitochondrial gene expression by interacting with several transcription factors. White adipose tissue (WAT) mainly comprises adipocytes that
Masaki Kobayashi, Yusuke Deguchi, Yuka Nozaki, Y. Higami   +3 more
semanticscholar   +1 more source

Mechanisms and Effects of Dietary Restriction on CNS and Affective Disorders

Acta Medica Bulgarica, 2020
Neuropsychiatric disorders, including depression contribute significantly to global disability and possess high social and health burden. Management is dominated by pharmacotherapy and psychotherapy; nevertheless, such treatments prevent or treat less ...
Haritov E., Garalova M., Tivcheva J., Angelov T., Stamenov V.   +4 more
doaj   +1 more source

Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer Immunotherapy

Cancers, 2021
Simple Summary Reduced food intake significantly enhances healthy lifespan in both model animals and humans, and decreases the incidence of cancer and other age-related diseases.
Erwan Eriau, J. Paillet, G. Kroemer, Jonathan G. Pol   +3 more
semanticscholar   +1 more source

PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons

Aging, 2021
Caloric restriction has been shown to robustly ameliorate age-related diseases and to prolong lifespan in several model organisms, and these beneficial effects are dependent on the stimulation of autophagy.
Marisa Ferreira-Marques, André Carvalho, C. Cavadas, C. Aveleira   +3 more
semanticscholar   +1 more source

Effect of Mediterranean diet and Mediterranean diet plus calorie restriction on cognition, lifestyle, and cardiometabolic health: A randomized clinical trial

Preventive Medicine Reports, 2022
A Mediterranean diet and intentional weight loss each positively affect cognitive functioning. Combining both could produce synergistic effects on cognition.
Lisa Tussing-Humphreys, Melissa Lamar, Andrew McLeod, Linda Schiffer, Lara Blumstein, Roxanne Dakers, Aimee Karstens, Nefertiti Oji Njideka Hemphill, Desmona Strahan, Leilah Siegel, Jennifer Sanchez Flack, Mirjana Antonic, Leo Restrepo, Michael Berbaum, Marian Fitzgibbon   +14 more
doaj   +1 more source

Calorie restriction regime enhances physical performance of trained athletes

Journal of the International Society of Sports Nutrition, 2018
Background Caloric restriction induces mitochondrial biogenesis and improves physical fitness in rodents. We aimed to provide evidence of how caloric restriction affects the body composition and physical performance of trained athletes and to evaluate ...
Victoria Pons, Joan Riera, Xavier Capó, Miquel Martorell, Antoni Sureda, Josep A. Tur, Franchek Drobnic, Antoni Pons   +7 more
doaj   +1 more source

Beneficial Effects of Caloric Restriction on Chronic Kidney Disease in Rodent Models: A Meta-Analysis and Systematic Review.

PLoS ONE, 2015
BackgroundNumerous studies have demonstrated the life-extending effect of caloric restriction. It is generally accepted that caloric restriction has health benefits, such as prolonging lifespan and delaying the onset and progression of CKD in various ...
Xiao-Meng Xu, Guang-Yan Cai, Ru Bu, Wen-Juan Wang, Xue-Yuan Bai, Xue-Feng Sun, Xiang-Mei Chen   +6 more
doaj   +1 more source

Caloric Restriction Mimetics: Metabolic Interventions [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2001
Caloric restriction (CR) retards diseases and aging in laboratory rodents and is now being tested in nonhuman primates. One way to apply these findings to human health is to identify and test agents that may mimic critical actions of CR. Panel 2 focused on two outcomes of CR, reduction of oxidative stress and improved glucoregulation, for which ...
R, Weindruch, K P, Keenan, J M, Carney, G, Fernandes, R J, Feuers, R A, Floyd, J B, Halter, J J, Ramsey, A, Richardson, G S, Roth, S R, Spindler   +10 more
openaire   +2 more sources

Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome

Journal of Endocrinological Investigation, 2021
Weight loss in patients with metabolic syndrome has positive effects on cardiovascular and type 2 diabetes risks, but its effects on peripheral cytokines and lipid profiles in patients are still unclear.
L. Montefusco, F. D’Addio, C. Loretelli, M. Ben Nasr, M. Garziano, A. Rossi, I. Pastore, L. Plebani, M. E. Lunati, A. Bolla, M. Porta, G. Piuri, F. Rocchio, A. Abdelsalam, E. Assi, M. Barichella, A. Maestroni, V. Usuelli, L. Loreggian, F. Muzio, G. Zuccotti, R. Cazzola, P. Fiorina   +22 more
semanticscholar   +1 more source