Results 41 to 50 of about 6,057,016 (284)

Game-theoretical description of the go-or-grow dichotomy in tumor development for various settings and parameter constellations

Scientific Reports, 2023
A medically important feature of several types of tumors is their ability to “decide” between staying at a primary site in the body or leaving it and forming metastases. The present theoretical study aims to provide a better understanding of the ultimate
Shalu Dwivedi, Christina Glock, Sebastian Germerodt, Heiko Stark, Stefan Schuster   +4 more
doaj   +1 more source

Head circumference as an epigenetic risk factor for maternal nutrition

Frontiers in Nutrition, 2022
Nutrition indicators for malnutrition can be screened by many signs such as stunting, underweight or obesity, muscle wasting, and low caloric and nutrients intake. Those deficiencies are also associated with low socioeconomic status.
Maria J. Miele, Renato T. Souza, Iracema M. Calderon, Francisco E. Feitosa, Debora F. Leite, Debora F. Leite, Edilberto A. Rocha Filho, Janete Vettorazzi, Jussara Mayrink, Karayna G. Fernandes, Karayna G. Fernandes, Matias C. Vieira, Matias C. Vieira, Rodolfo C. Pacagnella, Jose G. Cecatti, Preterm SAMBA study group   +15 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechanisms of consummatory vs. anticipatory responses through a symptom provocation paradigm

Frontiers in Behavioral Neuroscience
This functional magnetic resonance imaging (fMRI) study examined resting-state (RS) connectivity in adolescent and adult patients with anorexia nervosa (AN) using symptom provocation paradigms.
Andrea Mendez-Torrijos, Mageshwar Selvakumar, Silke Kreitz, Silke Kreitz, Julie Roesch, Arnd Dörfler, Georgios Paslakis, Johannes Krehbiel, Sabine Steins-Löber, Oliver Kratz, Stefanie Horndasch, Andreas Hess, Andreas Hess, Andreas Hess   +13 more
doaj   +1 more source

Magneto-thermal properties and slow magnetic relaxation in Mn(II)Ln(III) complexes: influence of magnetic coupling on the magneto-caloric effect.

Dalton Transactions, 2022
A family of Mn(II)Ln(III) dinuclear and tetranuclear complexes (Ln = Gd and Dy) has been prepared from the compartmental ligands N,N'-dimethyl-N,N'-bis(2-hydroxy-3-formyl-5-bromobenzyl)ethylenediamine (H2L1) and N,N',N''-trimethyl-N,N''-bis(2-hydroxy-3 ...
I. Oyarzabal, A. Zabala‐Lekuona, A. Mota, M. Palacios, A. Rodrı́guez-Diéguez, G. Lorusso, M. Evangelisti, Corina Rodríguez-Esteban, E. Brechin, J. Seco, E. Colacio   +10 more
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Time line of redox events in aging postmitotic cells

eLife, 2013
The precise roles that oxidants play in lifespan and aging are still unknown. Here, we report the discovery that chronologically aging yeast cells undergo a sudden redox collapse, which affects over 80% of identified thiol-containing proteins. We present
Nicolas Brandes, Heather Tienson, Antje Lindemann, Victor Vitvitsky, Dana Reichmann, Ruma Banerjee, Ursula Jakob   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Oxi-Inflamm-Aging: a New Theory with Practical Implications

Medisur, 2016
Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune dysregulation leads to a chronic low-grade inflammatory state in aging. This is the basis of the new integrative
Ángel Julio Romero Cabrera, Leocadia Amores Hernández   +1 more
doaj   +2 more sources

Historical analysis of the concept of Heat in Joule`s papers and possible implications for Physical Education

Investigações em Ensino de Ciências, 2017
This paper aimed to carry out an analysis of Joule’s original texts, written in the middle of the XIX century, trying to understand how the changes in heat concept occurred throughout his work. To support the theoretical analysis, a literature review was
Bianca Cintra de Carvalho, Luciano Carvalhais Gomes   +1 more
doaj   +1 more source