Results 41 to 50 of about 14,317 (273)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Time line of redox events in aging postmitotic cells

eLife, 2013
The precise roles that oxidants play in lifespan and aging are still unknown. Here, we report the discovery that chronologically aging yeast cells undergo a sudden redox collapse, which affects over 80% of identified thiol-containing proteins. We present
Nicolas Brandes, Heather Tienson, Antje Lindemann, Victor Vitvitsky, Dana Reichmann, Ruma Banerjee, Ursula Jakob   +6 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Oxi-Inflamm-Aging: a New Theory with Practical Implications

Medisur, 2016
Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune dysregulation leads to a chronic low-grade inflammatory state in aging. This is the basis of the new integrative
Ángel Julio Romero Cabrera, Leocadia Amores Hernández   +1 more
doaj   +2 more sources

Historical analysis of the concept of Heat in Joule`s papers and possible implications for Physical Education

Investigações em Ensino de Ciências, 2017
This paper aimed to carry out an analysis of Joule’s original texts, written in the middle of the XIX century, trying to understand how the changes in heat concept occurred throughout his work. To support the theoretical analysis, a literature review was
Bianca Cintra de Carvalho, Luciano Carvalhais Gomes   +1 more
doaj   +1 more source

Dietary fat supplements influence weight gain and egg production, but not offspring sex ratios in Japanese quail, Coturnix coturnix japonica

Journal of Avian Biology, 2023
Sex ratio theory suggests that females should bias offspring sex ratios based on maternal condition and the availability of critical food resources. Work in birds indicates that females do, indeed, bias sex ratios according to maternal condition and food
James Curry, Woo Yun Kim, Mary T. Mendonça, Kristen J. Navara   +3 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Fiber Optic Sensors for Vital Signs Monitoring. A Review of Its Practicality in the Health Field

Biosensors, 2021
Vital signs not only reflect essential functions of the human body but also symptoms of a more serious problem within the anatomy; they are well used for physical monitoring, caloric expenditure, and performance before a possible symptom of a massive ...
Christian Perezcampos Mayoral, Jaime Gutiérrez Gutiérrez, José Luis Cano Pérez, Marciano Vargas Treviño, Itandehui Belem Gallegos Velasco, Pedro António Hernández Cruz, Rafael Torres Rosas, Lorenzo Tepech Carrillo, Judith Arnaud Ríos, Edmundo López Apreza, Roberto Rojas Laguna   +10 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The nature of heat: after two centuries, will it be that the caloric theory is still in some way an attractive idea or, even, useful?

Semina: Ciências Exatas e Tecnológicas, 2009
In the beginning of the 19th Century, there were two theories absolutely different on the nature of the heat: the Mechanical Theory of the Heat and the Caloric Theory.
Antônio Bráz de Pádua, Cléia Guiotti de Pádua, Ricardo Spagnuolo Martins   +2 more
doaj