Results 151 to 160 of about 28,252 (277)

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Transcriptional regulation of ventral hippocampus-nucleus accumbens circuit excitability drives cocaine seeking. [PDF]

Sci Adv
Eagle AL, Sugimoto C, Doyle MA, Anderson D, Mousavi SL, Dykstra MM, Kuhn HM, Murray BR, Bastle RM, Simmons S, He J, Maze I, Mazei-Robison MS, Robison AJ.   +13 more
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Pro-inflammatory LPS drives production and release of the chemokine MCP-1 in human coronary artery smooth muscle cells. [PDF]

Mol Cell Biochem
Bankell E, Gidlöf O, Nilsson BO.
europepmc   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Antibodies to Tick Salivary Antigens AV422 and Calreticulin in Patients With Spotted Fever Group Rickettsioses and Other Febrile Illnesses in Northern Tanzania. [PDF]

J Infect Dis
Moorthy GS, Blocher BH, Madut DB, Miller HK, Perniciaro JL, Halliday JEB, Mmbaga BT, Lwezaula BF, Cleaveland S, Maro VP, Crump JA, Nicholson WL, Rubach MP.   +12 more
europepmc   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis. [PDF]

Nat Commun
Negishi H, Wada Y, Shirasaki Y, Hayashi T, Kubota Y, Iwasaki T, Kurosawa M, Ban T, Muto D, Suenaga Y, Kojima T, Matsuda Y, Irish SL, Dodo K, Suzuki T, Yamagishi M, Temizoz B, Yoshimori A, Kanai C, Nagasaki Y, Ohmuraya M, Tamura T, Iwama A, Inada T, Kuroda E, Kobiyama K, Toyama-Sorimachi N, Takekawa M, Coban C, Ishii KJ.   +29 more
europepmc   +1 more source

Thrombospondin-1 triggers calreticulin expression in human mucoepidermoid carcinoma MC-3 cells via the PERK/CHOP pathway. [PDF]

Oncol Lett
Bao S, Zhu Y, Guo L, Yang S.
europepmc   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source