Results 61 to 70 of about 5,102,780 (337)
Exuberance, A Motivation for Language [PDF]
, 1988 The following is part of the presidential address from Allen Walker Read, given before LACUS (Linguistic Association of Canada and the United States) at its annual meeting, August 7, 1987, at York University, Toronto, Ontario, Canada. It is reprinted by
Read, Allen Walker
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
First Nations Child and Family Services and Indigenous Knowledge as a Framework for Research, Policy and Practice [PDF]
, 2002 This paper provides an overview of the exciting national developments in First Nations child and family service delivery in Canada with a focus on progressive research, policy and practice.
Bennett, Marlyn, Blackstock, Cindy
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\u3ci\u3eSminthurus Mencenbergae,\u3c/i\u3e New Species from Canada and Michigan (Collembola: Sminthuridae) [PDF]
, 2017 A new species, Sminthurus (Sminthurus) mencenbergar Snider, is described from Canada and ...
Snider, Richard J
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Un estudio exploratorio de las experiencias de las personas trans en educación física
Arxius de Ciències SocialsLa literatura coincide en señalar que la asignatura de Educación física (EF) refleja y remarca las desigualdades existentes en la sociedad. Para las personas trans, la EF puede resultar especialmente difícil debido a los discursos binarios del género ...
Elena López-Cañada
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Lunch on School Days in Canada: Examining Contributions to Nutrient and Food Group Intake and Differences across Eating Locations [PDF]
, 2020 Claire N. Tugault-Lafleur +1 more
openalex +1 more source
, 2015 Excerpt: The first Europeans to inhabit what is now Canada came from Norse countries about 1000 AD to spend at least two winters at L’Anse aux Meadows, on the northwestern tip of Newfoundland.
Badley, Ken
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source