Results 161 to 170 of about 6,619,981 (269)

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading

, 2017
Anna Baulies, Joan Montero, Núria Matías, Naroa Insausti-Urkia, Oihana Terrones, Gorka Basáñez, Carmen G. Vallejo, Laura Conde de la Rosa, Laura Martínez-Gili, David Robles, Albert Morales, Joaquín Abián, Montserrat Carrascal, Keigo Machida, Dinesh Babu Uthaya Kumar, Hidekazu Tsukamoto, Neil Kaplowitz, Carmen García‐Ruiz, José C. Fernández‐Checa   +18 more
openalex   +1 more source

Treatment patterns and outcomes of unresectable pancreatic cancer patients in real-life practice: a region-wide analysis [PDF]

, 2018
Takeshi Terashima, Tatsuya Yamashita, Akito Sakai, Hajime Ohta, Yoshinobu Hinoue, Daisyu Toya, Hiroshi Kawai, Manabu Yonejima, Takeshi Urabe, Yatsugi Noda, Eishiro Mizukoshi, Shuichi Kaneko   +11 more
openalex   +1 more source

BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer

, 2022
Kun Li, Yanan Liu, Yi� Ding, Zhengwei Zhang, Juanjuan Feng, Jiaxin Hu, Jiwei Chen, Zhengke Lian, Yiliang Chen, Kewen Hu, Zhi Chen, Zhenyu Cai, Mingyao Liu, Xiufeng Pang   +13 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Transient loss of Polycomb components induces an epigenetic cancer fate

Victoria Parreno, Vincent Loubière, Bernd Schuettengruber, Lauriane Fritsch, Chetan C. Rawal, Maksim Erokhin, Balázs Győrffy, Davide Normanno, Marco Di Stefano, Jérôme Moreaux, Nadejda Butova, Irene Chiolo, Darya Chetverina, Anne‐Marie Martinez, Giacomo Cavalli   +14 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Development and pilot testing of AYA-RISE, a risk information and screening education intervention for adolescents and young adults with cancer risk syndromes. [PDF]

Fam Cancer
Kamihara J, Fisher L, Schienda J, Vanderwall R, Snir M, Snir G, Simmons E, Khalaj A, Goler E, Hamilton KV, Porter CC, Pencheva B, Schiffman JD, Maese LD, Kohlmann W, Henderson TO, Garber JE, Diller LR, Desai AV, Savage S, Klosky JL, Rana HQ, Mack JW.   +22 more
europepmc   +1 more source

Tumor PD-L1 status and CD8+ tumor-infiltrating T cells: markers of improved prognosis in oropharyngeal cancer

, 2017
Astrid De Meulenaere, Tijl Vermassen, Sandrine Aspeslagh, Philippe Deron, Fréderic Duprez, Debby Laukens, Jo Van Dorpe, Liesbeth Ferdinande, Sylvie Rottey   +8 more
openalex   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source