Results 111 to 120 of about 3,550,326 (312)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

55. Virtual Surgical Planning Flattens the Learning Curve for Free Fibula Flaps: A Comparative Analysis Between Junior and Senior Attendings in 561 Cases

Plastic and Reconstructive Surgery, Global Open, 2022
J. Michael Smith, MD, Luke Grome, MD, Jordan Kaplan, MD, Alexander F. Mericli, MD, Rene D. Largo, MD, Z-Hye Lee, MD, Jun Liu, PhD, Patrick B. Garvey, MD   +7 more
doaj   +1 more source

Effects of intrafractional diaphragm motion on dose perturbation in stereotactic body radiation therapy for lower thoracic vertebrae

Physics and Imaging in Radiation Oncology
Background and Purpose: This study aimed to evaluate the impact of intrafractional diaphragm motion (IFDM) on dose accuracy in stereotactic body radiation therapy (SBRT) for lower thoracic vertebrae.
Fumiyasu Matsubayashi, Kosuke Matsuura, Yasushi Ito, Yasuo Yoshioka   +3 more
doaj   +1 more source

A Unique Anti-Cancer 3-Styrylchromone Suppresses Inflammatory Response via HMGB1-RAGE Signaling. [PDF]

Medicines (Basel), 2021
Abe H, Okazawa M, Oyama T, Yamazaki H, Yoshimori A, Kamiya T, Tsukimoto M, Takao K, Sugita Y, Sakagami H, Abe T, Tanuma SI.   +11 more
europepmc   +1 more source

Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3 epsilon

, 2008
[[abstract]]To determine the role of 14-3-3 in colorectal cancer apoptosis induced by nonsteroidal anti-inflammatory drugs (NSAIDs), we evaluated the effects of sulindac on 14-3-3 epsilon protein expression in colorectal cancer cells.
Liou, JY; Ghelani, D; Yeh, S; Wu, KK
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Outcomes and toxicities after proton partial breast radiotherapy for early stage, hormone receptor positive breast cancer: 3-Year results of a phase II multi-center trial. [PDF]

Clin Transl Radiat Oncol, 2022
Choi JI, Prabhu K, Hartsell WF, DeWees T, Sinesi C, Vargas C, Benda RK, Cahlon O, Chang AL.   +8 more
europepmc   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

P405: INHIBITION OF CKS1-DEPENDENT PROTEOSTASIS REVEALS VULNERABILITIES IN LEUKAEMIC STEM CELLS WITH CONCOMITANT PROTECTION OF HEALTHY HAEMATOPOIETIC STEM CELLS

HemaSphere, 2022
W. Grey, A. Rio-Machin, P. Casado-Izquierdo, E. Gronroos, S. Ali, J. Miettinen, F. Bewicke-Copley, A. Parsons, C. Heckman, C. Swanton, P. Cutillas, J. Gribben, J. Fitzgibbon, D. Bonnet   +13 more
doaj   +1 more source

Impact of body surface area on efficacy and safety in patients with EGFR-mutant non-small cell lung cancer treated with osimertinib as a first-line treatment

Cancer Treatment and Research Communications
Background: The most recommended treatment for stage IV EGFR-positive lung cancer is osimertinib monotherapy. The dosage of osimertinib is fixed at 80 mg/day regardless of body surface area (BSA), however some patients withdraw or reduce the dosage due ...
Saki Tanaka, Motohiro Tamiya, Satoshi Nishiuma, Sayaka Nakamura, Keisuke Nozaki, Naoko Watanabe, Chisae Itoh, Yukio Kadokawa, Kenji Takeda, Kozo Takahashi, Akito Miyazaki, Takahisa Kawamura, Kei Kunimasa, Takako Inoue, Kazumi Nishino, Mari Takagi   +15 more
doaj   +1 more source