Results 91 to 100 of about 3,550,326 (312)

Infection with hepatitis viruses, FIB-4 index and risk of hepatocellular carcinoma in southern Italy: a population-based cohort study

Infectious Agents and Cancer, 2016
Background The incidence of hepatocellular carcinoma (HCC) and its association with hepatitis C (HCV) and hepatitis B virus (HBV) infections, FIB-4 index and liver enzymes was assessed in an area of the province of Naples covered by a population-based ...
Mario Fusco, Pierluca Piselli, Saverio Virdone, Pietro Di Cicco, Paola Scognamiglio, Paolo De Paoli, Valerio Ciullo, Diana Verdirosi, Michele D’Orazio, Luigino Dal Maso, Enrico Girardi, Silvia Franceschi, Diego Serraino   +12 more
doaj   +1 more source

Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]

, 2003
Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Krishnan, S., Witton, C.J., Edwards, J., Bartlett, J.M.S.   +3 more
core  

Cervical cancer screening programmes and policies in 18 European countries. [PDF]

, 2004
A questionnaire survey was conducted by the Epidemiology Working Group of the European Cervical Cancer Screening Network, and the International Agency for Research on Cancer, IARC, between August and December 2003 in 35 centres in 20 European countries ...
Weiderpass, E, Ronco, G., Hakama, M., Anttila, A, Clifford, G, Hakama, M, G Ronco, G Clifford, E Weiderpass, M Hakama, Bray, F., F Bray, M Arbyn, Bray, F, Ronco, G, Weiderpass, E., Arbyn, M, A Anttila, Clifford, G., Anttila, A., Arbyn, M.   +20 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Lobar or sublobar resection for early-stage second primary lung cancer ≤ 3 cm in size: a SEER population-based study. [PDF]

J Cancer Res Clin Oncol, 2023
Zhao K, Xia C, Qiu M, Yang Z, Cui T, Song T, Li S, Mei H, Zheng Y, Wang H.   +9 more
europepmc   +1 more source

Diabetes alone should not be a reason for withholding adjuvant chemotherapy for stage III colon cancer

, 2011
Background: With increasing prevalence of diabetes mellitus and colon cancer, the number of patients suffering from both diseases is growing, and physicians are being faced with complicated treatment decisions.
Wouter M. W. Dercksen, Extermann, Martine, Harm R. Haak, Janssen-Heijnen, Maryska L.G., van de Schans, Saskia A.M., Haak, Harm R., Dercksen, Wouter M.W., Maren A. van Waalwijk, Martine Extermann, van Waalwijk, Maren A., Saskia A. M. van de Schans, Maryska L. G. Janssen-Heijnen   +11 more
core   +1 more source

Galectin 3 for the diagnosis of bladder cancer

Arab Journal of Urology, 2014
To evaluate serum levels of galectin-3 (G-3) in patients with bladder cancer and a control group, as a potential diagnostic and prognostic serum tumour marker.Between November 2012 and January 2013, 55 patients (median age 58 years) were enrolled into three groups, i.e., a control, those with transitional cell carcinoma (TCC) or those with squamous ...
El Gendy, Hoda, Madkour, Bothina, Abdelaty, Sara, Essawy, Fayza, Khattab, Dina, Hammam, Olfat, El Kholy, Amr, Nour, Hani H.   +7 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source