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Hyaluronidases in cancer biology
Seminars in Cancer Biology, 2008Hyaluronan is a megadalton glycosaminoglycan polymer critical for maintaining the integrity of the extracellular matrix. It can exist in a protein-bound state with aggregating proteoglycans, where it expands the extracellular matrix and modulates cell-cell interactions.
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Current Opinion in Oncology, 1993
New treatments of lung cancer are likely to develop from a greater understanding of the biology of lung tumors and the mechanisms of carcinogenesis and tumor progression. It is clear that numerous molecular genetic changes are present in lung cancer. Some of these changes, eg, mutated oncogenes, are found in other tumors.
J A, Ledermann, R L, Souhami
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New treatments of lung cancer are likely to develop from a greater understanding of the biology of lung tumors and the mechanisms of carcinogenesis and tumor progression. It is clear that numerous molecular genetic changes are present in lung cancer. Some of these changes, eg, mutated oncogenes, are found in other tumors.
J A, Ledermann, R L, Souhami
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Current Opinion in Oncology, 1993
Recent studies have begun to elucidate the molecular events involved in the development of ovarian cancer. First, it has been shown that epithelial ovarian cells both produce and have receptors for many peptide growth factors. It is possible that these growth factors may participate in autocrine and paracrine growth-regulatory pathways in these cells ...
M P, Boente +4 more
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Recent studies have begun to elucidate the molecular events involved in the development of ovarian cancer. First, it has been shown that epithelial ovarian cells both produce and have receptors for many peptide growth factors. It is possible that these growth factors may participate in autocrine and paracrine growth-regulatory pathways in these cells ...
M P, Boente +4 more
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2011
The process of carcinogenesis involves a number of changes in cellular phenotype, which are largely based on acquired genetic changes in cells that are not terminally differentiated. The ability of cancer cells to grow and their failure to respond to the usual controls on such proliferation are obvious features, but they also evade cell death and most ...
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The process of carcinogenesis involves a number of changes in cellular phenotype, which are largely based on acquired genetic changes in cells that are not terminally differentiated. The ability of cancer cells to grow and their failure to respond to the usual controls on such proliferation are obvious features, but they also evade cell death and most ...
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The Cancer Journal, 2010
Significant advances have been made in understanding the biology of colorectal cancer. In this chapter, we review the key signaling pathways that play key roles in maintaining the growth and proliferation of colorectal cancer. The pathways that will be discussed include Wnt/beta-catenin, TGF-beta/SMAD, Notch, Hedgehog, epidermal growth factor receptor,
Muhammad Wasif, Saif, Edward, Chu
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Significant advances have been made in understanding the biology of colorectal cancer. In this chapter, we review the key signaling pathways that play key roles in maintaining the growth and proliferation of colorectal cancer. The pathways that will be discussed include Wnt/beta-catenin, TGF-beta/SMAD, Notch, Hedgehog, epidermal growth factor receptor,
Muhammad Wasif, Saif, Edward, Chu
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Seminars in Cancer Biology, 2008
Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and ...
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Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and ...
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Evolutionary biology of cancer
Trends in Ecology & Evolution, 2005Cancer is driven by the somatic evolution of cell lineages that have escaped controls on replication and by the population-level evolution of genes that influence cancer risk. We describe here how recent evolutionary ecological studies have elucidated the roles of predation by the immune system and competition among normal and cancerous cells in the ...
Bernard, Crespi, Kyle, Summers
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Cancer, 1991
The greatest risk factor for cancer is aging. Human cancer incidence increases exponentially with advancing age. Cancer growth rate and potential for metastatic spread may be influenced by age-specific change in host response. Because cancer and aging are, thus, inextricably linked, the American Cancer Society should encourage submission of research ...
F F, Holmes +5 more
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The greatest risk factor for cancer is aging. Human cancer incidence increases exponentially with advancing age. Cancer growth rate and potential for metastatic spread may be influenced by age-specific change in host response. Because cancer and aging are, thus, inextricably linked, the American Cancer Society should encourage submission of research ...
F F, Holmes +5 more
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The biology of cancer genetics
Seminars in Oncology Nursing, 2004To review cancer biology and associated genetic change.Professional journals, texts, monographs, and Internet websites.Several types of genetic damage occur in cancer cells: activation of protooncogenes into oncogenes that give cells an abnormal growth advantage; inactivation of tumor suppressor genes that would normally slow or stop abnormal cell ...
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The molecular biology of cancer
Molecular Aspects of Medicine, 2000The process by which normal cells become progressively transformed to malignancy is now known to require the sequential acquisition of mutations which arise as a consequence of damage to the genome. This damage can be the result of endogenous processes such as errors in replication of DNA, the intrinsic chemical instability of certain DNA bases or from
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