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International Journal of Oncology, 1997
Cancer cachexia is a complex syndrome accounting for nearly a third of cancer deaths, characterized by weight loss, anorexia, weakness, anaemia and asthenia. The complications associated with the appearance of the cachectic syndrome affect both the physiological and biochemical balance of the patient, and have effects on the efficiency of the ...
J, Argiles, F, Lopezsoriano
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Cancer cachexia is a complex syndrome accounting for nearly a third of cancer deaths, characterized by weight loss, anorexia, weakness, anaemia and asthenia. The complications associated with the appearance of the cachectic syndrome affect both the physiological and biochemical balance of the patient, and have effects on the efficiency of the ...
J, Argiles, F, Lopezsoriano
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International journal of pancreatology, 1990
Cancer cachexia has been listed as a major cause of death in cancer patients. In order to investigate the metabolic effects of the tumor on the host, we have evaluated an experimental model of cancer cachexia in the mouse (MAC16 colon adenocarcinoma), in which weight loss can reach 30-40% of initial weight with a tumor burden of only 2.5%, without a ...
M J, Tisdale, S A, Beck
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Cancer cachexia has been listed as a major cause of death in cancer patients. In order to investigate the metabolic effects of the tumor on the host, we have evaluated an experimental model of cancer cachexia in the mouse (MAC16 colon adenocarcinoma), in which weight loss can reach 30-40% of initial weight with a tumor burden of only 2.5%, without a ...
M J, Tisdale, S A, Beck
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International Journal of Cardiology, 2002
Cancer cachexia is a complex, multifactorial syndrome that results from a reduction in food intake, a variety of metabolic abnormalities (including hypermetabolism) or more often a combination of the two. Multiple mediator pathways including pro-inflammatory cytokines, neuroendocrine hormones and tumour-specific factors are involved. Therapy requires a
Kenneth C H, Fearon, Alastair G W, Moses
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Cancer cachexia is a complex, multifactorial syndrome that results from a reduction in food intake, a variety of metabolic abnormalities (including hypermetabolism) or more often a combination of the two. Multiple mediator pathways including pro-inflammatory cytokines, neuroendocrine hormones and tumour-specific factors are involved. Therapy requires a
Kenneth C H, Fearon, Alastair G W, Moses
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Surgical Oncology, 1999
Cachexia is a common cause of morbidity and mortality in patients with advanced cancer. It is characterised by numerous metabolic abnormalities including inefficient substrate utilisation, alterations in the balance of energy intake and expenditure and the acute-phase protein response.
M D, Barber, J A, Ross, K C, Fearon
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Cachexia is a common cause of morbidity and mortality in patients with advanced cancer. It is characterised by numerous metabolic abnormalities including inefficient substrate utilisation, alterations in the balance of energy intake and expenditure and the acute-phase protein response.
M D, Barber, J A, Ross, K C, Fearon
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Critical Reviews in Oncology/Hematology, 1987
Cancer cachexia is a complex syndrome that includes host tissue wasting, anorexia, asthenia, and abnormal host intermediary metabolism. It is present in approximately 50% of cancer patients during treatment and nearly 100% of treated cancer patients at death. Cachexia has a detrimental impact on cancer therapy. The central problem of cancer cachexia is
Jeffrey A. Norton +3 more
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Cancer cachexia is a complex syndrome that includes host tissue wasting, anorexia, asthenia, and abnormal host intermediary metabolism. It is present in approximately 50% of cancer patients during treatment and nearly 100% of treated cancer patients at death. Cachexia has a detrimental impact on cancer therapy. The central problem of cancer cachexia is
Jeffrey A. Norton +3 more
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Nature Reviews Disease Primers, 2018
Cancer-associated cachexia is a disorder characterized by loss of body weight with specific losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination of reduced food intake and metabolic changes, including elevated energy expenditure, excess catabolism and inflammation.
Vickie E Baracos +2 more
exaly +5 more sources
Cancer-associated cachexia is a disorder characterized by loss of body weight with specific losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination of reduced food intake and metabolic changes, including elevated energy expenditure, excess catabolism and inflammation.
Vickie E Baracos +2 more
exaly +5 more sources
Cancer, 1979
Cancer cachexia is characterized clinically by anorexia, early satiety, weight loss. anemia, and marked asthenia. The syndrome is not the result of semistarvation alone but it represents a complex metabolic problem. In the host there are abnormalities in metabolism of energy, carbohydrate, lipid and protein, in water content, in acid-base balance, in ...
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Cancer cachexia is characterized clinically by anorexia, early satiety, weight loss. anemia, and marked asthenia. The syndrome is not the result of semistarvation alone but it represents a complex metabolic problem. In the host there are abnormalities in metabolism of energy, carbohydrate, lipid and protein, in water content, in acid-base balance, in ...
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Anamorelin for cancer cachexia
Drugs of Today, 2022Cancer anorexia-cachexia syndrome is a multifactorial condition characterized by significant weight loss due to muscle loss. It is associated with functional impairment, changes in body composition and nutritional disorders. Ghrelin receptors are involved in the release of growth hormone (GH) in the pituitary gland and increase appetite via the ...
Kenichi, Nishie +2 more
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Cachexia in patients with cancer
The Lancet Oncology, 2016Muscle radiation attenuation is inversely related to muscle fat content and is independently associated with muscle strength. 4 Understanding the impact of anamorelin on muscle composition and quality is crucial, and remains the unmeasured variable that could greatly help explain the discordance in this study between the increase in lean body mass ...
Grant R, Williams +2 more
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Hematology/Oncology Clinics of North America, 1991
It is currently hypothesized that the mechanisms of cancer cachexia involve the host's production of inflammatory cytokines, which in turn orchestrate a series of complex interrelated steps that ultimately lead to a chronic state of wasting, malnourishment, and death (see Fig. 1).
H N, Langstein, J A, Norton
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It is currently hypothesized that the mechanisms of cancer cachexia involve the host's production of inflammatory cytokines, which in turn orchestrate a series of complex interrelated steps that ultimately lead to a chronic state of wasting, malnourishment, and death (see Fig. 1).
H N, Langstein, J A, Norton
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