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Endocrinopathies and cancer cachexia
Current Opinion in Supportive & Palliative Care, 2019Purpose of review Cancer cachexia cannot be easily reversed by standard nutritional support and interventions directed at underlying metabolic derangements may be needed to prevent or reverse cachexia and maintain healthy body composition.
Rony, Dev +2 more
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Cancer Cachexia and Cannabinoids
Complementary Medicine Research, 1999Anorexia and cachexia are diagnosed in more than two-thirds of all cancer patients with advanced disease, and are independent risk factors for morbidity and mortality. Anorexia, nausea and vomiting often are described as more significant inhibiting factors for quality of life of cancer patients than even intense pain.
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Nutrition, 2001
Patients with cancer cachexia experience a profound wasting of adipose tissue and lean body mass. Anorexia, although often present, is insufficient to account for tissue wasting because 1) cachexia involves massive depletion of skeletal muscle that does not occur during anorexia, 2) nutritional supplementation cannot replenish the loss of lean body ...
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Patients with cancer cachexia experience a profound wasting of adipose tissue and lean body mass. Anorexia, although often present, is insufficient to account for tissue wasting because 1) cachexia involves massive depletion of skeletal muscle that does not occur during anorexia, 2) nutritional supplementation cannot replenish the loss of lean body ...
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Hospital Practice, 1993
A by-product of cancer (and of other chronic diseases or severe trauma), cachexia appears to be mediated by various cytokines. The first to be identified--tumor necrosis factor--may be a principal mediator. With molecular cloning techniques, future treatment strategies could include blockade of TNF activity using highly specific reagents.
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A by-product of cancer (and of other chronic diseases or severe trauma), cachexia appears to be mediated by various cytokines. The first to be identified--tumor necrosis factor--may be a principal mediator. With molecular cloning techniques, future treatment strategies could include blockade of TNF activity using highly specific reagents.
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Surgical Oncology Clinics of North America, 2001
The provision of additional calories and protein alone has not been shown to be efficacious in patients with cancer cachexia. Although primary research continues to unravel the complex metabolic derangements and diverse mediator pathways underlying cancer cachexia, the future lies in drugs and neutracenticals that may modulate this altered metabolism ...
K C, Fearon, M D, Barber, A G, Moses
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The provision of additional calories and protein alone has not been shown to be efficacious in patients with cancer cachexia. Although primary research continues to unravel the complex metabolic derangements and diverse mediator pathways underlying cancer cachexia, the future lies in drugs and neutracenticals that may modulate this altered metabolism ...
K C, Fearon, M D, Barber, A G, Moses
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AACN Clinical Issues: Advanced Practice in Acute & Critical Care, 2000
The diagnosis of cancer has traditionally been associated with malnutrition and wasting. Oncology patients are at risk for nutrition-related problems because of the cancer itself, as well as the treatment prescribed. Clinical manifestations of cachexia include anorexia, weight loss, muscle wasting, and fatigue, resulting in poor performance status ...
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The diagnosis of cancer has traditionally been associated with malnutrition and wasting. Oncology patients are at risk for nutrition-related problems because of the cancer itself, as well as the treatment prescribed. Clinical manifestations of cachexia include anorexia, weight loss, muscle wasting, and fatigue, resulting in poor performance status ...
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1999
This chapter will address a number of issues regarding cancer anorexia/ cachexia. These include (1) the significance of this clinical problem; (2) potential mechanisms that cause cancer anorexia/cachexia; (3) mechanisms for studying antidotes for cancer anorexia/cachexia; (4) clinical trials of potential drugs; and (5) current recommendations for the ...
R M, Goldberg, C L, Loprinzi
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This chapter will address a number of issues regarding cancer anorexia/ cachexia. These include (1) the significance of this clinical problem; (2) potential mechanisms that cause cancer anorexia/cachexia; (3) mechanisms for studying antidotes for cancer anorexia/cachexia; (4) clinical trials of potential drugs; and (5) current recommendations for the ...
R M, Goldberg, C L, Loprinzi
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The Role of Cytokines in Cancer Cachexia
Current Opinion in Supportive & Palliative Care, 2007The present investigation is devoted to uncovering the different signaling pathways - particularly transcriptional factors - involved in muscle wasting.Although the search for the cachectic factor(s) started a long time ago, and although many scientific and economic efforts have been devoted to its discovery, we are still a long way from knowing the ...
Josep M, Argilés +3 more
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Pathophysiology of cancer cachexia
Supportive Care in Cancer, 1993Patients with advanced cancer and cachexia typically demonstrate modestly increased rates of energy expenditure in the presence of diminished food intake due to anorexia and to gastrointestinal disturbances. Rates of glucose production by the liver, gluconeogenesis and glycolysis to lactate (Cori cycle) are increased, fat mobilisation and oxidation are
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Physiological Reviews, 2009
Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a shortened survival time. Anorexia often accompanies cachexia, but appears not to be responsible for the tissue loss, particularly lean body mass.
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Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a shortened survival time. Anorexia often accompanies cachexia, but appears not to be responsible for the tissue loss, particularly lean body mass.
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