Results 51 to 60 of about 3,014,693 (296)

The regulatory approval of anamorelin for treatment of cachexia in patients with non‐small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer in Japan: facts and numbers.

Journal of Cachexia, Sarcopenia and Muscle, 2021
Anamorelin is a ghrelin receptor agonist that can be administered orally and thought to improve cancer cachexia by improving appetite and increasing serum insulin‐like growth factor‐1. Anamorelin was not approved for use in Europe.
Hidetaka Wakabayashi, Hidenori Arai, Akio Inui   +2 more
doaj   +1 more source

Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series. [PDF]

Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints.
Hjermstad, MJ, McMillan, D, Bye, A, Arends, J, Sayers, J, Sousa, MS, Leesahatsawat, K, Simpson, MR, Skipworth, RJE, Ottestad, IO, Fallon, M, Balstad, TR, McDonald, J, Cancer Cachexia Endpoints Working Group,, Anker, SD, Brown, LR, Vagnildhaug, OM, Laird, BJA, Solheim, TS, Philips, I, Dolan, RD, Thompson, J, Jakobsen, G, McGovern, J, Roeland, EJ, Dajani, O, Yule, MS   +26 more
core   +1 more source

Adipose depot gene expression and intelectin-1 in the metabolic response to cancer and cachexia [PDF]

, 2020
Background Cancer cachexia is a poorly understood metabolic consequence of cancer. During cachexia, different adipose depots demonstrate differential wasting rates.
Gallagher, Iain J, Gallagher, Iain J., Skipworth, Richard, Skipworth, Richard J E, Dreczkowski, Gillian, Miller, Janice, Ramage, Michael, Stephen J. Wigmore, Wigmore, Stephen, Wigmore, Stephen J, Richard J.E. Skipworth, Ramage, Michael I, Janice Miller, Iain J. Gallagher, Gillian Dreczkowski, Michael I. Ramage   +15 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

The Role of Nurse in the Multidisciplinary Management of Cancer Cachexia

Asia-Pacific Journal of Oncology Nursing, 2021
Cancer cachexia is a complex syndrome for which multidisciplinary management through collaboration has the potential to improve patient outcomes and efficiency of care, through the integration of nursing into practice.
Yiyuan Zhao, Dong Pang, Yuhan Lu
doaj   +1 more source

Discrepancies Between Micro Versus Macroscale Viscoelastic Properties in a Microplastic‐Tissue Composite Model

Advanced Engineering Materials, EarlyView.
This study explores the discrepancies between bulk mechanics and spatial mapping in a tissue‐mimetic hydrogel model. Microplastic particles create localized stiff mechanical microenvironments that are detectable by cellular‐scale nanoindentation but leave bulk properties unchanged as measured by rheology.
Ahron T. Verschleisser, Baptiste Le Roi, Omri Leshem, Joshua M. Grolman   +3 more
wiley   +1 more source

PROTEOLYSIS AND AUTOPHAGY IN THE VASTUS LATERALIS OF PATIENTS WITH BRONCHIECTASIS-ASSOCIATED SARCOPENIA: ROLE IN TRAINING PROGRAMS

Open Respiratory Archives
Introduction: Muscle dysfunction or sarcopenia is a systemic manifestation of chronic respiratory diseases such as COPD and non-cystic fibrosis (non-CF) bronchiectasis.
Cinta Cumplí Gargallo, Adriana Núñez-Robainas, Mariela Alvarado-Miranda, Marina Sáinz, Esther Barreiro   +4 more
doaj   +1 more source

Non-coding RNAs in cancer-associated cachexia: clinical implications and future perspectives

Translational Oncology, 2021
Cachexia is a multifactorial syndrome characterized by skeletal muscle loss, with or without adipose atrophy, irreversible through nutritional support, in the context of systemic inflammation and metabolic disorders.
Anastasia Kottorou, Foteinos-Ioannis Dimitrakopoulos, Aspasia Tsezou   +2 more
doaj   +1 more source

Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series. [PDF]

Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints.
McMillan, DC, Hjermstad, MJ, Maddocks, M, Bye, A, Arends, J, Sayers, J, Sousa, MS, Simpson, MR, Skipworth, RJE, Ottestad, IO, Balstad, TR, Greil, C, McDonald, J, Cancer Cachexia Endpoints Working Group,, Brown, LR, Vagnildhaug, OM, Laird, BJA, Solheim, TS, Baracos, VE, Dolan, RD, Jakobsen, G, Phillips, I, Dajani, O, Fallon, MT, Yule, MS   +24 more
core   +1 more source

Self‐Sintering Ionogel Binder for Flexible, Recyclable, and Healable Printed Giant Magnetoresistive Sensors

Advanced Functional Materials, EarlyView.
ABSTRACT Electronic waste has emerged as a major environmental challenge, driven by the massive consumption and a limited lifetime of modern electronic devices, stimulating the development of sustainable electronics. Here, an all‐biomaterial gelatin‐choline‐citric acid ([Ch][CA]) ionogel is developed as an active binder to realize self‐sintered ...
Lin Guo, Xiaotao Wang, Guannan Mu, Proloy Taran Das, Igor Veremchuk, Conrad Schubert, Aaron D. Cross, Yevhen Zabila, Xuan Peng, Larysa Baraban, Denys Makarov   +10 more
wiley   +1 more source