Results 41 to 50 of about 3,014,693 (296)

Investigating Differential StressResponse between the Extraocular and Tibialis Anterior Muscles under the Influence of Cancer Cachexia

, 2023
reservedCancer cachexia, a debilitating syndrome causing muscle wasting, significantly affects cancer patients' survival and quality of life. This study investigates the differential response of extraocular muscles (EOMs) and tibialis anterior (TA ...
SHARAWY, MARWAN MOHAMED NABIL MOHAMAD
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series. [PDF]

There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value.
Hjermstad, MJ, Bye, A, Grzyb, A, Arends, J, Ottestad, I, Sayers, J, Sousa, MS, Simpson, MR, Skipworth, RJE, Fallon, M, Balstad, TR, Greil, C, McDonald, J, Cancer Cachexia Endpoints Working Group,, Fraser, E, Dajani, OF, Vagnildhaug, OM, Brown, LR, Laird, BJA, Baracos, V, Solheim, TS, Philips, I, Dolan, RD, Jakobsen, G, Kaasa, S   +24 more
core   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Systemic inflammation and oxidative stress in bronchiectasis-associated sarcopenia

ERJ Open Research
Introduction Sarcopenia has recently been associated with bronchiectasis. We hypothesised that inflammation and oxidative stress are elevated in both systemic and muscle compartments in patients with bronchiectasis-associated sarcopenia, even in the ...
Adriana Núñez-Robainas, Mariela Alvarado-Miranda, Alberto Solano, Salvatore Marsico, Maria Cinta Cumpli-Gargallo, Marina Sáinz-Hernández, José María Maiques, Esther Barreiro   +7 more
doaj   +1 more source

Potential role of immunological factors in early diagnosis of cancer cachexia in C26 tumor-bearing mice

Applied Biological Chemistry, 2019
Cachexia is a wasting syndrome associated with high mortality in cancer patients through inducing the failure of normal metabolism and reducing the efficacy of cancer treatment. Thus, it is critically important to diagnose cancer cachexia early.
Jae Eun Ju, Mi-Sook Kim, Joo Hyun Kang, Ji Young Lee, Mi So Lee, Eun Ho Kim, Namhyun Chung, Youn Kyoung Jeong   +7 more
doaj   +1 more source

Understanding Cachexia in Head and Neck Cancer

Asia-Pacific Journal of Oncology Nursing, 2021
One of the major comorbidities of cancer and cancer therapy is posing a global health problem in cancer cachexia. Cancer cachexia is now considered a multifactorial syndrome that presents with drastic loss of body weight, anorexia, asthenia, and anemia ...
Sivaramakrishnan Muthanandam, Jananni Muthu   +1 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source