Palliative stenting for oesophagogastric cancer: tumour and host factors and prognosis [PDF]
, 2018 Objectives: Palliative self-expandable metallic stent (SEMS) insertion is common in patients not suitable for resection of oesophagogastric (OG) cancer. Factors which may determine survival, however, are not clear.
Glen, Paul +3 more
core +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis
Cells, 2021 We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI).
Laura Mañas-García +5 more
doaj +1 more source
Health care professionals’ experience, understanding and perception of need of advanced cancer patients with cachexia and their families: The benefits of a dedicated clinic. [PDF]
, 2016 BACKGROUND: Cachexia is defined as the on-going loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support. It is found in up to 80% of patients with advanced cancer and has profound psycho-social consequences for ...
CM Holden +31 more
core +1 more source
4D Mapping of ZIF Biocomposites for High Protein Loading and Tunable Release Profiles
Advanced Functional Materials, EarlyView.Systematic four‐dimensional mapping of zeolitic imidazolate framework biocomposites reveals how precursor ratios, total concentration, and washing define crystalline phase, protein loading, and release kinetics. This comprehensive study identifies conditions yielding record loading (∼85%) and precise phase–property correlations.
Michael R. Hafner +12 more
wiley +1 more source
Signaling networks governing skeletal muscle growth, atrophy, and cachexia
Skeletal MuscleMaintaining skeletal muscle mass and strength is essential for healthy aging and overall longevity. Muscle mass is governed by a complex network of signaling pathways that coordinate proteostasis and regulate the expression of anabolic and catabolic ...
Aniket S Joshi +3 more
doaj +1 more source
Lipids in Health and Disease, 2018 Background Cancer cachexia is a progressive and multi-factorial metabolic syndrome characterized by loss of adipose tissue and skeletal muscle. White adipose tissue (WAT) lipolysis and white-to-brown transdifferentiation of WAT (WAT browning) are ...
Jun Han +3 more
doaj +1 more source
Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential. [PDF]
PLoS ONE, 2018 Cancer cachexia is a severe, debilitating condition characterized by progressive body wasting associated with remarkable loss of skeletal muscle weight.
Shoya Inaba +4 more
doaj +1 more source
Kaheksia kanker dan tatalaksana nutrisi pada penderita kanker
JKS (Jurnal Kedokteran Syiah Kuala), 2021 Abstrak. Gangguan status nutrisi pada penderita kanker yang disebut dengan kaheksia kanker merupakan masalah yang serius. Kaheksia kanker dikarakteristikkan dengan penurunan berat badan, kelemahan otot dan anoreksia. Insidensi kaheksia kanker berkisar 40-
Huwainan Nisa Nasution
doaj +1 more source
Pancreas Cancer-Associated Weight Loss. [PDF]
, 2019 Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality.
Denlinger, Crystal S +7 more
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