Results 91 to 100 of about 18,416,887 (403)

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing

Molecular Cancer, 2023
Background Chimeric Antigen Receptor (CAR) T cells are now standard of care (SOC) for some patients with B cell and plasma cell malignancies and could disrupt the therapeutic landscape of solid tumors.
Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G. Mancini, Gavin L. Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J. Fisher, Annie K. Brown, Ramya H. Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L. Mackall, Steven A. Feldman   +16 more
doaj   +1 more source

Cancer stem cells from colorectal cancer-derived cell lines [PDF]

Proceedings of the National Academy of Sciences, 2010
Cancer stem cells (CSCs) are the subpopulation of cells within a tumor that can self-renew, differentiate into multiple lineages, and drive tumor growth. Here we describe a two-pronged approach for the identification and characterization of CSCs from colorectal cancer cell lines, using a Matrigel-based differentiation assay, and cell ...
Yeung, T, Gandhi, S, Wilding, J, Muschel, R, Bodmer, W   +4 more
openaire   +2 more sources

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Genetic and transcriptional evolution alters cancer cell line drug response

Nature, 2018
Human cancer cell lines are the workhorse of cancer research. Although cell lines are known to evolve in culture, the extent of the resultant genetic and transcriptional heterogeneity and its functional consequences remain understudied.
U. Ben-David, B. Siranosian, G. Ha, Helen Tang, Yaara Oren, Kunihiko Hinohara, C. Strathdee, Joshua M. Dempster, Nicholas J. Lyons, Robert T. Burns, Anwesha Nag, G. Kugener, Beth A. Cimini, Peter Tsvetkov, Y. Maruvka, Ryan O’Rourke, Anthony J. Garrity, Andrew A. Tubelli, P. Bandopadhayay, Aviad Tsherniak, F. Vazquez, Bang Wong, Chet Birger, M. Ghandi, A. Thorner, Joshua A. Bittker, M. Meyerson, G. Getz, R. Beroukhim, T. Golub   +29 more
semanticscholar   +1 more source

Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo [PDF]

, 2015
Violacein (VIO; 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one), an indole-derived purple-colored pigment, produced by a limited number of Gram-negative bacteria species, including Chromobacterium ...
Bei, Roberto, Benvenuto, Monica, DI STEFANO, Enrica, Fantini, Massimo, LA REGINA, Giuseppe, Manzari, Vittorio, Masuelli, Laura, Mattei, Maurizio, Mattera, Rosanna, Modesti, Andrea, Pantanella, Fabrizio, Schippa, Serena, Silvestri, Romano   +12 more
core   +1 more source

Developmental Disorders in Children Recently Diagnosed With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag, Long Vu, Ritika Miryala, Jeffrey M. Albert, Molly McVoy, Siran M. Koroukian   +5 more
wiley   +1 more source

The Continuous Concentration of Particles and Cancer Cell Line Using Cell Margination in a Groove-Based Channel

Micromachines, 2017
In the capillary venules, blood cells auto-separate with red blood cells aggregating near the centre of vessel and the nucleated cells marginating toward the wall of vessel. In this experiment, we used cell margination to help enrich the Jurkat cells via
Sheng Yan, Dan Yuan, Qianbin Zhao, Jun Zhang, Weihua Li   +4 more
doaj   +1 more source

Mutant p53 as a guardian of the cancer cell

Cell Death and Differentiation, 2018
Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a ...
F. Mantovani, Licio Collavin, G. Del Sal
semanticscholar   +1 more source

Cells, Stem Cells, and Cancer Stem Cells [PDF]

Seminars in Reproductive Medicine, 2013
The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Aguilar-Gallardo, C, Simon, C
openaire   +4 more sources