Results 131 to 140 of about 18,416,887 (403)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Final Fate of Cancer Cells After Nuclear Genetic Material Damage
Zhongliu Fangzhi YanjiuCancer cells refer to a group of malignant cells with strong division and proliferation abilities. Cancer cells rely on the unstable plunder of human nutrition to sustain the large amount of energy that they need for their own division and proliferation.
Lei WANG +4 more
doaj +1 more source
Main Group Metal Chemistry, 2018 In this study, two new metal-organic frameworks, namely, {(H2NMe2)[Zn3LiO(BTA)2](DMF)3}n (1, H3BTA=3,3′,3″-[1,3,5-benzenetriyltris(carbonylimino)] trisbenzoic acid) and {(Me2NH2)2[In2(TTA)2(FBA)2](DMF)3}n (2, H3TTA=4,4′-(((5-((4-(hydroxy-l2-methoxy ...
Meng Xian-Qing +3 more
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Role of CTCF in the regulation of microRNA expression
Frontiers in Genetics, 2012 MicroRNAs (miRNAs) are small non-coding RNAs that regulate expression of various target genes. MiRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Epigenetic alterations such as
Yoshimasa eSaito, Hidetsugu eSaito
doaj +1 more source
Cancer Cell Membrane-Coated Nanoparticles for Cancer Management
Cancers, 2019 Cancer is a global health problem in need of transformative treatment solutions for improved patient outcomes. Many conventional treatments prove ineffective and produce undesirable side effects because they are incapable of targeting only cancer cells ...
Jenna C. Harris +2 more
semanticscholar +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
2D and 3D cell cultures – a comparison of different types of cancer cell cultures
Archives of medical science : AMS, 2016 Cell culture is a widely used in vitro tool for improving our understanding of cell biology, tissue morphology, and mechanisms of diseases, drug action, protein production and the development of tissue engineering.
Marta Kapałczyńska +9 more
semanticscholar +1 more source
New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]
, 2008 The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin +8 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source