Results 171 to 180 of about 18,416,887 (403)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

AngioCRIME in Acute Myeloid Leukemia (AML)

HemaSphere, 2017
Elizabeth Macintyre, for Passaro et al. Cancer Cell   +1 more
doaj   +1 more source

Chinese Expert Consensus on Next Generation Sequencing Diagnosis 
for Non-small Cell Lung Cancer (2020 Edition)

Chinese Journal of Lung Cancer, 2020
Chinese Society of Clinical Oncology, Expert Committee on Non-small Cell Lung Cancer
doaj   +1 more source

Next-generation characterization of the Cancer Cell Line Encyclopedia

Nature, 2019
M. Ghandi, F. Huang, Judit Jané-Valbuena, G. Kryukov, Christopher C. Lo, E. McDonald, J. Barretina, Ellen T. Gelfand, C. Bielski, Haoxin Li, K. Hu, Alexander Y. Andreev-Drakhlin, Jaegil Kim, J. Hess, B. Haas, F. Aguet, B. Weir, M. Rothberg, B. Paolella, M. Lawrence, Rehan Akbani, Yiling Lu, Hong L. Tiv, P. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, J. Shih, Kevin Hadi, Yanay Rosen, J. Bistline, K. Venkatesan, Anupama Reddy, D. Sonkin, Manway Liu, J. Lehár, Joshua M. Korn, D. Porter, Michael D. Jones, J. Golji, G. Caponigro, Jordan E. Taylor, C. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, A. Kauffmann, Nicolas Stransky, M. Imieliński, Y. Maruvka, A. Cherniack, Aviad Tsherniak, F. Vazquez, Jacob D. Jaffe, A. Lane, D. Weinstock, Cory M. Johannessen, Michael P. Morrissey, F. Stegmeier, R. Schlegel, W. Hahn, G. Getz, G. Mills, J. Boehm, T. Golub, L. Garraway, W. Sellers   +67 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18 [PDF]

, 2014
Keng Zhong, Kun Chen, Lin Han, Bailing Li   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Overview of distinct 8-oxoguanine profiles of messenger RNA in normal and senescent cancer cells

Frontiers in Cell and Developmental Biology
BackgroundCellular senescence plays a key role in the development of cancer, but the underlying mechanisms are unknown. Recently, several recent studies have shown that RNA methylation is closely related to cancer cell aging.
Jingwen Huang, Yu Lin, Yingying Zhao, Lingbo Wei   +3 more
doaj   +1 more source

Comparison of Epidermal Growth Factor Receptor Mutation Statuses in Tissue and Plasma in Stage I–IV Non-Small Cell Lung Cancer Patients [PDF]

, 2012
Xiao Zhao, Rubing Han, Jing Zhao, Jun Wang, Fan Yang, Wei Zhong, Li Zhang, Longyun Li, Mengzhao Wang   +8 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source