Results 41 to 50 of about 1,007,573 (266)
Immunology of Cell Death in Cancer Immunotherapy [PDF]
Cells, 2021 Over the last two decades, a large volume of studies has established that dying and dead cancer cells exert a potent immunomodulatory effect on their immediate microenvironment, which has a major influence on the anticancer immunity [...]
Galluzzi, Lorenzo, Garg, Abhishek D.
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Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System
Cells, 2021 Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and human health. Impaired apoptosis is associated with a variety of human diseases, including neurodegenerative disorders, autoimmunity and cancer.
Ruqaia Abbas, Sarit Larisch
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Cancer and programmed cell death.
Genome biology, 2003 A report on the 15th Lorne Cancer Conference, Lorne, Australia, 13-16 February 2003.
Croker, Ben, Hart, Adam
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LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Nature Communications, 2018 TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal ...
Lucia Taraborrelli +19 more
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The V-ATPases in cancer and cell death
Cancer Gene Therapy, 2022 Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases, also known as H+-ATPases, are large multi-subunit protein complexes composed of a peripheral domain (V1) responsible for the hydrolysis of ATP and a membrane-integrated domain (V0 ...
Fangquan Chen +3 more
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When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
Cells, 2014 Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis.
Ditte Marie Brix +2 more
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Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer
Cell Death Discovery, 2022 Senescence is believed to be a pivotal player in the onset and progression of tumors as well as cancer therapy. However, the guiding roles of senescence in clinical outcomes and therapy selection for patients with cancer remain obscure, largely due to ...
Lulin Zhou +13 more
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How to Choose the Right Inducible Gene Expression System for Mammalian Studies?
Cells, 2019 Inducible gene expression systems are favored over stable expression systems in a wide variety of basic and applied research areas, including functional genomics, gene therapy, tissue engineering, biopharmaceutical protein production and drug discovery ...
Tuula Kallunki +3 more
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SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes
Cell Reports, 2016 Recruitment of the deubiquitinase CYLD to signaling complexes is mediated by its interaction with HOIP, the catalytically active component of the linear ubiquitin chain assembly complex (LUBAC).
Sebastian Kupka +6 more
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Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair
Nature Communications, 2017 The role of annexins in cell membrane repair is largely undefined. Here the authors use a model lipid bilayer to show that annexin A4 induces curvature at the membrane free edge and annexin A6 induces constriction force, and find that both annexins are ...
Theresa Louise Boye +7 more
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