Results 21 to 30 of about 1,007,573 (266)
Cell Death and Disease, 2023 SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral cancer cells.
Srimanta Patra +8 more
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Colorectal Cancer Stem Cells and Cell Death [PDF]
Cancers, 2011 Nowadays it is reported that, similarly to other solid tumors, colorectal cancer is sustained by a rare subset of cancer stem–like cells (CSCs), which survive conventional anticancer treatments, thanks to efficient mechanisms allowing escape from apoptosis, triggering tumor recurrence. To improve patient outcomes, conventional anticancer therapies have
Catalano V. +6 more
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Tumor endothelial cell autophagy is a key vascular‐immune checkpoint in melanoma
EMBO Molecular Medicine, 2023 Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune‐excluded tumor phenotype. However, the molecular mechanisms that sustain TEC‐mediated immunosuppression remain largely elusive.
Jelle Verhoeven +24 more
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Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Nature Communications, 2020 Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death.
Saara Hämälistö +11 more
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Entosis: The emerging face of non-cell-autonomous type IV programmed death
Biomedical Journal, 2017 The present review summarizes recent experimental evidences about the existence of the non-cell-autonomous death entosis in physiological and pathophysiological contexts, discusses some aspects of this form of cell death, including morphological ...
Isabelle Martins +10 more
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Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models
Cells, 2021 Chordomas are rare, slow-growing tumors of the axial skeleton. These tumors are locally aggressive and refractory to conventional therapies. Radical surgery and radiation remain the first-line treatments.
Marie-Anaïs Locquet +13 more
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Modes of Regulated Cell Death in Cancer [PDF]
Cancer Discovery, 2021 Abstract Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD modalities, namely apoptosis, entosis, necroptosis, pyroptosis, and ferroptosis. We explore how various RCD modules
Elle, Koren, Yaron, Fuchs
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Macrophage biology plays a central role during ionizing radiation-elicited tumor response
Biomedical Journal, 2017 Radiation therapy is one of the major therapeutic modalities for most solid tumors. The anti-tumor effect of radiation therapy consists of the direct tumor cell killing, as well as the modulation of tumor microenvironment and the activation of immune ...
Qiuji Wu +5 more
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ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport
Frontiers in Cell and Developmental Biology, 2022 Membrane contact sites (MCS) between organelles of eukaryotic cells provide structural integrity and promote organelle homeostasis by facilitating intracellular signaling, exchange of ions, metabolites and lipids and membrane dynamics.
Maria Livia Sassano +5 more
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Targeting immunogenic cell death in cancer [PDF]
Molecular Oncology, 2020 Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts.
Ahmed, Asma, Tait, Stephen W.G.
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