Results 21 to 30 of about 1,010,020 (219)
When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
Cells, 2014 Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis.
Ditte Marie Brix +2 more
doaj +1 more source
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer
Cell Death Discovery, 2022 Senescence is believed to be a pivotal player in the onset and progression of tumors as well as cancer therapy. However, the guiding roles of senescence in clinical outcomes and therapy selection for patients with cancer remain obscure, largely due to ...
Lulin Zhou +13 more
doaj +1 more source
How to Choose the Right Inducible Gene Expression System for Mammalian Studies?
Cells, 2019 Inducible gene expression systems are favored over stable expression systems in a wide variety of basic and applied research areas, including functional genomics, gene therapy, tissue engineering, biopharmaceutical protein production and drug discovery ...
Tuula Kallunki +3 more
doaj +1 more source
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes
Cell Reports, 2016 Recruitment of the deubiquitinase CYLD to signaling complexes is mediated by its interaction with HOIP, the catalytically active component of the linear ubiquitin chain assembly complex (LUBAC).
Sebastian Kupka +6 more
doaj +1 more source
Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair
Nature Communications, 2017 The role of annexins in cell membrane repair is largely undefined. Here the authors use a model lipid bilayer to show that annexin A4 induces curvature at the membrane free edge and annexin A6 induces constriction force, and find that both annexins are ...
Theresa Louise Boye +7 more
doaj +1 more source
eLife, 2022 Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome instability to uncontrolled proliferation or invasion. Cancer cells are constantly challenged by mechanical stresses not only in the primary tumour but also during ...
Deborah Fanfone +13 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi +10 more
wiley +1 more source
BECLIN-1/BECN1 at the barrier: a gatekeeper of epithelial and endothelial homeostasis
Autophagy ReportsEpithelial and endothelial barriers are essential for tissue homeostasis, protecting the body from environmental insults while regulating selective transport. The integrity of these barriers relies on dynamic intercellular junctions whose composition and
Juliani Juliani +2 more
doaj +1 more source
Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism
Frontiers in Immunology, 2018 Lack of immune system cells or impairment in differentiation of immune cells is the basis for many chronic diseases. Metabolic changes could be the root cause for this immune cell impairment.
Anusha Angajala +7 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier +10 more
wiley +1 more source