Results 1 to 10 of about 1,009,921 (120)
Scientific Reports, 2021 In cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease.
Marie-Anaïs Locquet +6 more
doaj +1 more source
Cells, 2022 The recent discovery demonstrating that the leakage of cathepsin B from mitotic lysosomes assists mitotic chromosome segregation indicates that lysosomal membrane integrity can be spatiotemporally regulated.
Jonathan Stahl-Meyer +4 more
doaj +1 more source
Radiotherapy in bone sarcoma: the quest for better treatment option
BMC Cancer, 2023 Bone sarcomas are rare tumors representing 0.2% of all cancers. While osteosarcoma and Ewing sarcoma mainly affect children and young adults, chondrosarcoma and chordoma have a preferential incidence in people over the age of 40.
Marie-Anaïs Locquet +3 more
doaj +1 more source
Cells, 2022 Cancer is one of the leading causes of death worldwide, thus the search for new cancer therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene with a wide range of pharmacological activities including anti ...
Ditte L. Fogde +9 more
doaj +1 more source
Cell Death and Disease, 2023 SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral cancer cells.
Srimanta Patra +8 more
doaj +1 more source
Tumor endothelial cell autophagy is a key vascular‐immune checkpoint in melanoma
EMBO Molecular Medicine, 2023 Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune‐excluded tumor phenotype. However, the molecular mechanisms that sustain TEC‐mediated immunosuppression remain largely elusive.
Jelle Verhoeven +24 more
doaj +1 more source
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Nature Communications, 2020 Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death.
Saara Hämälistö +11 more
doaj +1 more source
Entosis: The emerging face of non-cell-autonomous type IV programmed death
Biomedical Journal, 2017 The present review summarizes recent experimental evidences about the existence of the non-cell-autonomous death entosis in physiological and pathophysiological contexts, discusses some aspects of this form of cell death, including morphological ...
Isabelle Martins +10 more
doaj +1 more source
Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models
Cells, 2021 Chordomas are rare, slow-growing tumors of the axial skeleton. These tumors are locally aggressive and refractory to conventional therapies. Radical surgery and radiation remain the first-line treatments.
Marie-Anaïs Locquet +13 more
doaj +1 more source
Macrophage biology plays a central role during ionizing radiation-elicited tumor response
Biomedical Journal, 2017 Radiation therapy is one of the major therapeutic modalities for most solid tumors. The anti-tumor effect of radiation therapy consists of the direct tumor cell killing, as well as the modulation of tumor microenvironment and the activation of immune ...
Qiuji Wu +5 more
doaj +1 more source