Results 11 to 20 of about 1,007,573 (266)
The Death of the Cancer Cell [PDF]
Cancer Research, 2011 AbstractFor a century, the perception that there are qualitative differences between a normal cell and a cell belonging to a tumor has dominated discussions aimed at explaining cancer. However, an analysis of the experimental evidence suggests that individual normal cells and individual cancer cells share the same two fundamental behavioral properties,
Carlos, Sonnenschein, Ana M, Soto
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Programmed Cell Death in Cancer Cells [PDF]
Klinicka onkologie, 2014 Resistance to programmed cell death is one of the hallmarks of cancer cells that affects the process of malignant transformation as well as response to cancer therapy. The goal of this review is to summarize recent information about programmed cell death (PCD) in healthy and cancer cells, as well as new perspectives for anticancer treatments targeting ...
E, Ondroušková, B, Vojtěšek
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Scientific Reports, 2021 In cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease.
Marie-Anaïs Locquet +6 more
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Autophagic Cell Death and Cancer [PDF]
International Journal of Molecular Sciences, 2014 Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration.
Shigeomi Shimizu +3 more
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Cells, 2022 The recent discovery demonstrating that the leakage of cathepsin B from mitotic lysosomes assists mitotic chromosome segregation indicates that lysosomal membrane integrity can be spatiotemporally regulated.
Jonathan Stahl-Meyer +4 more
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Radiotherapy in bone sarcoma: the quest for better treatment option
BMC Cancer, 2023 Bone sarcomas are rare tumors representing 0.2% of all cancers. While osteosarcoma and Ewing sarcoma mainly affect children and young adults, chondrosarcoma and chordoma have a preferential incidence in people over the age of 40.
Marie-Anaïs Locquet +3 more
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Glutathione in Cancer Cell Death [PDF]
Cancers, 2011 Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation and death.
Ortega Valero, Ángel L. +2 more
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Autophagy in Cancer Cell Death [PDF]
Biology, 2019 Autophagy has important functions in maintaining energy metabolism under conditions of starvation and to alleviate stress by removal of damaged and potentially harmful cellular components. Therefore, autophagy represents a pro-survival stress response in the majority of cases.
Benedikt Linder, Donat Kögel
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Cells, 2022 Cancer is one of the leading causes of death worldwide, thus the search for new cancer therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene with a wide range of pharmacological activities including anti ...
Ditte L. Fogde +9 more
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Autophagy, cell death, and cancer [PDF]
Molecular & Cellular Oncology, 2015 Autophagy is an evolutionarily conserved intracellular catabolic process that is used by all cells to degrade dysfunctional or unnecessary cytoplasmic components through delivery to the lysosome. Increasing evidence reveals that autophagic dysfunction is associated with human diseases, such as cancer.
Lin, Lin, Baehrecke, Eric H
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