Results 171 to 180 of about 287,041 (297)

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Effects of pregnancy on breast cancer immunology: immune biomarker and TIL quantification. [PDF]

NPJ Breast Cancer
Galas K, Gleitsmann M, Rey J, Solbach C, Witzel I, Karn T, Schmatloch S, Schem C, Schneeweis A, Sinn B, Fehm T, Denkert C, Fasching P, Litmeyer AS, Marmé F, Jank P, Müller V, Seiler S, Stickeler E, Ortmann O, van Mackelenbergh M, Nekljudova V, Holtschmidt J, Loibl S.   +23 more
europepmc   +1 more source

Significance of regulatory T cells in cancer immunology and immunotherapy

, 2022
Daisuke Sugiyama, Kunihiko Hinohara, Hiroyoshi Nishikawa   +2 more
openalex   +1 more source

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Advanced Healthcare Materials, EarlyView.
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed   +6 more
wiley   +1 more source

1032 Early remodelling of CD4 T cell differentiation in lung squamous carcinogenesis

Journal for ImmunoTherapy of Cancer, 2023
Vítor Teixeira, Kate Davies, Peter Campbell, Bart Vanhaesebroeck, Sam Janes, Kate Gowers, Amalie Kai Bentzen, Teerapon Sahwangarrom, Claudia Peinador Marin, Sam Gamble, Zoe Whiteman, Seng Ung, Lukas Kalinke, Ahmed Alhendi, Adam Pennycuick, Sandra Gomez Lopez, Andrei Enica, Amber Rogers, Kane Foster, Moritz Przybilla, James L Reading   +20 more
doaj   +1 more source

MicroRNAs in Cancer Immunology: Master Regulators of the Tumor Microenvironment and Immune Evasion, with Therapeutic Potential. [PDF]

Cancers (Basel)
Zare E, Yaghoubi SM, Khoshnazar M, Jafari Dargahlou S, Machhar JS, Zheng Z, Duijf PHG, Mansoori B.   +7 more
europepmc   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Interstitial N‐Strengthened Copper‐Based Bioactive Conductive Dressings Combined with Electromagnetic Fields for Enhanced Wound Healing

Advanced Healthcare Materials, EarlyView.
This study developed a nitrogen‐strengthened copper‐iron‐zinc (N‐CuFeZn) alloy bioactive dressing integrated with electromagnetic stimulation. The coaxial dressing, made from 0.04 mm filaments with 1120 MPa tensile strength, showed that electromagnetic activation enhanced therapeutic outcomes by increasing VEGF expression, promoting angiogenesis (2.1 ...
Xiaohui Qiu, Xianrui Wu, Shaohua Wang, Jie Gu, Senhao Ying, Jiaohao Mo, Chen Jing, Huiliang Cao, Zhongchang Wang, Jianda Zhou   +9 more
wiley   +1 more source

Finding a needle in a haystack: functional screening for novel targets in cancer immunology and immunotherapies. [PDF]

Oncogene
Du Y, Yang Y, Zheng B, Zhang Q, Zhou S, Zhao L.   +5 more
europepmc   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source