Results 231 to 240 of about 539,919 (309)

Steroid Receptor Coactivator‐1 Drives Tumor‐Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural Invasion

Advanced Science, EarlyView.
Steroid receptor coactivator‐1 (SRC‐1) reprograms tumor‐associated macrophages (TAMs) via signal transducer and activator of transcription 1(STAT1)‐mediated matrix metallopeptidase 12 (MMP12) transcription to drive perineural invasion (PNI) in pancreatic cancer.
Ke Cheng, Liang Liu, Miaomiao Gong, Yuke Ji, Chunmei Bai, Xiangqian Guo, Hui Chen, Jinjin Pan, Ying Zhang, Yuhui Yuan   +9 more
wiley   +1 more source

Correction: Emerging strategies in colorectal cancer immunotherapy: enhancing efficacy and survival. [PDF]

Front Immunol
Zhang Y, Guan H, Feng X, Liu M, Shao J, Liu M, He J, Jin Y, Zhu J, Zheng C.   +9 more
europepmc   +1 more source

Data from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Mona Tomaschko, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Philip East, Kevin Litchfield, Se‐Hoon Lee, Míriam Molina‐Arcas, Julian Downward   +15 more
openalex   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Editorial: Monitoring the immune/tumor microenvironment to improve cancer immunotherapy. [PDF]

Front Immunol
Kim J, Kubelick KP.
europepmc   +1 more source

Faculty Opinions recommendation of CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy.

, 2019
Sergei B. Koralov, Elitza Ivanova
openalex   +2 more sources

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

CD47-Targeted Therapy in Cancer Immunotherapy: At a Crossroads of Promise and Challenge. [PDF]

Oncol Res
Guo X, Fu Y, Baran N, Ma W.
europepmc   +1 more source

[Radiotherapy Combined with Immunotherapy and Chemotherapy Improves Prognosis and Demonstrates Synergistic Effects in Extensive-stage Small Cell Lung Cancer].

Huaijun Ji, Meiling Sun, Jingyi Li, Ge Yu, Yongbing Chen   +4 more
openalex   +2 more sources