Results 261 to 270 of about 5,215,493 (360)

Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups

Advanced Materials, EarlyView.
An acid‐responsive polymeric micelle system based of aliphatic poly(carbonate)s with benzyl ketal side chains is designed for targeted immunodrug delivery. It can disassemble in endosomal environments, enabling site‐specific immunoactivation and enhanced biodegradability.
Adrian V. Hauck, Michael Fichter, Laura J. Rosenberger, Jannis Willig, Alexander Fuchs, Felicia Schön, Paul Schneider, Carolina Medina‐Montano, Taufiq Ahmad, Jessica Erlenbusch, Pol Besenius, Leonard Kaps, Matthias Bros, Stephan Grabbe, Volker Mailänder, Jürgen Groll, Lutz Nuhn   +16 more
wiley   +1 more source

Preclinical assessment of genetically modified exosomes for colorectal cancer immunotherapy. [PDF]

J Control Release
Hoang TO, Zhang L, Kim SH, Kao G, Shen K, Zhang Z, Yu PW, Lenz HJ, Zhang Y.   +8 more
europepmc   +1 more source

Mitochondria‐Targeted Nanomotor: H2S‐Driven Cascade Therapy for Hepatocellular Carcinoma

Advanced Materials, EarlyView.
A mitochondrial‐targeted nanomotor integrates photodynamic therapy, mild photothermal therapy, and enzyme dynamic therapy into a self‐amplifying cascade through H2S‐driven metabolic reprogramming. Abstract Despite advances in combination therapies for cancer treatment, most strategies rely on modular‐additive designs that lack dynamic molecular cues to
Chengcheng Li, Xiaodong Ma, Shiji Fang, Biao Chen, Xinru Wang, Lingyun He, Xin Yang, Yuanqiang Li, Jessica M. Rosenholm, Zhongwei Zhao, Jiansong Ji, Hongbo Zhang   +11 more
wiley   +1 more source

Hypochlorous Acid-Responsive Prodrug Nanoplatform for Synergistic Cancer Immunotherapy. [PDF]

Biomater Res
Xia S, Wang X, Liu C, Ji R, Wang M, Zhang C, Chen L, Chen W, Yao SQ, Fang C, Dong X.   +10 more
europepmc   +1 more source

Targeting Cancer Immunotherapy through Vaccination using Irradiated Xenogeneic Placental extract [PDF]

, 2018
Dalia A. Mostafa, Fatma Farag, Soheir El boushy, Asmaa Abu Bakr   +3 more
openalex   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

BTLA: An Emerging Immune Checkpoint Target in Cancer Immunotherapy. [PDF]

Pharmaceuticals (Basel)
Chang MC, Lee WC, Tai YJ, Chiang YC.
europepmc   +1 more source

Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer

Mengya Niu, Yihan Pei, Tiantian Jin, Jun-Xiu Li, Liming Bai, Cuixia Zheng, Qingling Song, Hongjuan Zhao, Yun Zhang, Lei Wang   +9 more
openalex   +1 more source

High‐Concentration Antibody Formulation via Solvent‐Based Dehydration

Advanced Materials, EarlyView.
Amorphous solid antibodies are encapsulated into hydrogel microparticles through a solvent‐based dehydration process. The solvent extracts water from antibody solution droplets, causing the antibody to concentrate, and precipitation of the antibody into amorphous solid is induced.
Talia Zheng, Lucas Attia, Janet Teng, Patrick S. Doyle   +3 more
wiley   +1 more source

Editorial: Immune-checkpoint inhibitors and immunometabolic reprogramming in cancer immunotherapy. [PDF]

Front Immunol
Kumar V, De Falco V.
europepmc   +1 more source