Results 261 to 270 of about 539,919 (309)

Neuromuscular complications associated with cancer immunotherapy. [PDF]

J Natl Cancer Cent
Xiong G, Lomen-Herth C, Richman D, Li T.
europepmc   +1 more source

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

Cascade amplification of therapeutic payloads for cancer immunotherapy. [PDF]

Commun Biol
Li Y, Wu J, Li N, Wu M, Wang Z, Li J, Zhang L.   +6 more
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Emerging strategies in colorectal cancer immunotherapy: enhancing efficacy and survival. [PDF]

Front Immunol
Zhang Y, Guan H, Feng X, Liu M, Shao J, Liu M, He J, Jin Y, Zhu J, Zheng C.   +9 more
europepmc   +1 more source

Identification of Siglec-10 as a new dendritic cell checkpoint for cervical cancer immunotherapy

Congwen Wang, Lewei He, Jing Peng, Chong Lu, Meng Zhang, Xingling Qi, Mingxing Zhang, Yumeng Wang   +7 more
openalex   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Sucralose Consumption Ablates Cancer Immunotherapy Response through Microbiome Disruption. [PDF]

Cancer Discov
Morder KM, Nguyen M, Wilfahrt DN, Dahmani ZL, Burr ABP, Xie B, Morikone M, Nieves-Rosado H, Gunn WG, Hurd DE, Wang H, Mullett SJ, Bossong K, Gelhaus SL, Rajasundaram D, Kane LP, Delgoffe GM, Das J, Davar D, Overacre-Delgoffe AE.   +19 more
europepmc   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Towards biomarker-driven cancer immunotherapy: the rising of a protein phosphatase regulator. [PDF]

Signal Transduct Target Ther
Liu X, Yang W, Cheng AS.
europepmc   +1 more source