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Combinatorial Cancer Immunotherapy
2006The formulation of therapeutic strategies to enhance immune-mediated tumor destruction is a central goal of cancer immunology. Substantive progress toward delineating the mechanisms involved in innate and adaptive tumor immunity has improved the prospects for crafting efficacious treatments.
F Stephen, Hodi, Glenn, Dranoff
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New England Journal of Medicine, 1977
Control of cancer by immunologic methods was first suggested by physicians who observed, more than a century ago, that advanced cancer occasionally underwent total regression after acute bacterial ...
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Control of cancer by immunologic methods was first suggested by physicians who observed, more than a century ago, that advanced cancer occasionally underwent total regression after acute bacterial ...
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Current Opinion in Pharmacology, 2013
The understanding that the immune system plays a dual role in cancer progression has led to the recent development of targeted immunotherapies. These treatments, which aim to harness the immune system against cancer, include monoclonal antibodies, immune adjuvants, cell-based therapy and vaccines.
Maya Zigler +2 more
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The understanding that the immune system plays a dual role in cancer progression has led to the recent development of targeted immunotherapies. These treatments, which aim to harness the immune system against cancer, include monoclonal antibodies, immune adjuvants, cell-based therapy and vaccines.
Maya Zigler +2 more
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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer.
CellThe immune checkpoint blockade (ICB) response in human cancers is closely linked to the gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is positively correlated with the responsiveness of ICB.
Dingjiacheng Jia +21 more
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Current Opinion in Urology, 2007
Basic immunology research over several decades has led to an improved understanding of tumor recognition by components of the immune system and mechanisms of tumor evasion from immune detection. These findings have ultimately led to four phase III trials, currently underway, evaluating antitumor active immunotherapies in patients with prostate cancer ...
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Basic immunology research over several decades has led to an improved understanding of tumor recognition by components of the immune system and mechanisms of tumor evasion from immune detection. These findings have ultimately led to four phase III trials, currently underway, evaluating antitumor active immunotherapies in patients with prostate cancer ...
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Annals of the New York Academy of Sciences, 1999
Abstract: The goal of cancer treatment is to develop modalities that specifically target tumor cells, thereby avoiding unnecessary side effects to normal tissue. Vaccine strategies that result in the activation of the immune system specifically against proteins expressed by a cancer have the potential to be effective treatment for this purpose.
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Abstract: The goal of cancer treatment is to develop modalities that specifically target tumor cells, thereby avoiding unnecessary side effects to normal tissue. Vaccine strategies that result in the activation of the immune system specifically against proteins expressed by a cancer have the potential to be effective treatment for this purpose.
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Intralesional Cancer Immunotherapies
Hematology/Oncology Clinics of North America, 2019Melanoma and other solid cancers with low or absent T-cell inflammation respond poorly to immune checkpoint inhibitors. Tumor infiltration with T cells that are directed against tumor antigens requires the induction of an innate immune response leading to production of type I interferons and maturation and activation of dendritic cells that can cross ...
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1989
When, in the 1960s Burnet’s immunosurveillance hypotheses became common knowledge among clinicians, many of them took it for granted that human tumors carried tumor antigens which allowed the host, theoretically, to recognize and reject his or her own cancer cells.
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When, in the 1960s Burnet’s immunosurveillance hypotheses became common knowledge among clinicians, many of them took it for granted that human tumors carried tumor antigens which allowed the host, theoretically, to recognize and reject his or her own cancer cells.
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Dynamics and specificities of T cells in cancer immunotherapy
Nature Reviews. Cancer, 2023G. Oliveira, Catherine J. Wu
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