Results 21 to 30 of about 897,136 (317)
Asian Journal of Pharmaceutical Sciences, 2020 Ursolic acid (UA), a natural pentacyclic triterpenoid, possesses widespread biological and pharmacological activities. However, drawbacks such as low bioavailability, poor targeting and rapid metabolism greatly hinder its further clinical application ...
Jingwei Shao +8 more
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Nature Communications, 2019 Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate ...
Xiaodong Xie +17 more
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On the Origin of Cancer Metastasis [PDF]
Critical Reviews in Oncogenesis, 2013 Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues and to distant organs and is the primary cause of cancer morbidity and mortality. In order to complete the metastatic cascade, cancer cells must detach from the primary tumor, intravasate into the circulatory and lymphatic systems, evade immune attack ...
Thomas N, Seyfried +1 more
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STAR Protocols, 2023 Summary: Organotypic brain cultures are short-term assays that phenotypically and functionally recapitulate brain metastatic cells in vivo. Here, we present a protocol to generate murine organotypic brain cultures for drug screening.
Lucía Zhu +4 more
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Autophagy in cancer metastasis [PDF]
Oncogene, 2016 Autophagy is a highly conserved self-degradative process that has a key role in cellular stress responses and survival. Recent work has begun to explore the function of autophagy in cancer metastasis, which is of particular interest given the dearth of effective therapeutic options for metastatic disease.
Mowers, E E, Sharifi, M N, Macleod, K F
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Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
Nature Communications, 2017 The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific.
Martin Teichert +13 more
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Metabolism in cancer metastasis [PDF]
International Journal of Cancer, 2015 Cancer metabolism has regained substantial research interest over recent years. The focus has been mostly on the primary tumor, while metabolic adjustments during dissemination have been less extensively researched. Deadhesion impairs glucose transport and brings about an ATP deficit that leads to apoptosis.
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The pathogenesis of cancer metastasis [PDF]
Nature, 1980 Metastases do not result from random survival of cells released from the primary tumour but from the selective growth of specialised subpopulations of highly metastatic cells endowed with specific properties that befit them to complete each step of the metastatic process.
G, Poste, I J, Fidler
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, 2023 Metastasis or recurrence following curative surgery is the main indicator of tumor progress and is the main cause of patient death. For more than three decades, the potential for general anesthesia to affect cancer outcomes has been a subject of concern ...
Ru Li +7 more
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PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment
Frontiers in Immunology, 2020 Background and AimsPyruvate kinase M2 (PKM2) is an essential regulator of the Warburg effect, but its biological function promoting immune escape of hepatocellular carcinoma (HCC) is unclear.MethodsGEPIA web tool and immunohistochemistry (IHC) analysis ...
Tian-En Li +14 more
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