Results 41 to 50 of about 897,136 (317)

Cancer, metastasis, and the epigenome

Molecular Cancer
AbstractCancer is the second leading cause of death worldwide and disease burden is expected to increase globally throughout the next several decades, with the majority of cancer-related deaths occurring in metastatic disease. Cancers exhibit known hallmarks that endow them with increased survival and proliferative capacities, frequently as a result of
Saurav Kiri, Tyrone Ryba
openaire   +3 more sources

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Narciclasine as a potential therapeutic agent to overcome EGFR-TKI resistance in non-small cell lung cancer

Journal of Translational Medicine
Background Non-small cell lung cancer (NSCLC) is associated with abnormal activation of the epidermal growth factor receptor (EGFR) due to overexpression or mutations.
Jee Young Sung, Ha-Eun Yoo, Soomi Kim, Suyeun Yu, Sang-Won Park, Ga-Eun Lim, Byung Il Lee, Kyungsil Yoon, Hyo Jung Kim, Sang-Ku Ye, Jaegal Shim, Yong-Nyun Kim   +11 more
doaj   +1 more source

Outward Movement of Targeting Ligands from a Built‐In Reserve Pool in Nuclease‐Resistant 3D Hierarchical DNA Nanocluster for in Vivo High‐Precision Cancer Therapy

Advanced Science, 2022
Nanostructures made entirely of DNAs display great potential as chemotherapeutic drug carriers but so far cannot achieve sufficient clinic therapy outcomes due to off‐target toxicity. In this contribution, an aptamer‐embedded hierarchical DNA nanocluster
Weijun Wang, Yansha Gao, Yaxin Chen, Wenqing Wang, Qian Li, Zhiyi Huang, Jingjing Zhang, Qi Xiang, Zai‐Sheng Wu   +8 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models [PDF]

, 2015
This research was financed in part by a Grant of the 7th Framework Program of the European Union (METOXIA project; HEALTH‐F2‐2009‐222741) and the NGI Pre- Seed grant (NWO n° 93613002).Triple negative, resistant or metastatic disease are major factors in ...
Kunkler, Ian H., Jarman, Edward J, Kunkler, Ian, Pavathaneni, Nanda- Kumar, Meehan, James, Jarman, Edward, Ward, Carol, Harrison, David James, Langdon, Simon P., Dixon, J. Michael, Um, In Hwa, Supuran, Claudiu, Lambin, Philippe, Winum, Jean-Yves, Um, Inhwa, Dixon, MIchael, Supuran, Claudiu Trandafir, Renshaw, Lorna, Harrison, David J, Dubois, Ludwig, Langdon, Simon, Thomas, Jeremy, Mullen, Peter, Kay, Charlene, Jarman, Edward J., Kay, Charlene; id_orcid, Supuran, Claudiu T, Harrison, David, Pavathaneni, Nanda-Kumar, Thomas, Jeremy S., Harrison, David J.   +30 more
core   +1 more source

SIPA1 Regulates LINC01615 to Promote Metastasis in Triple-Negative Breast Cancer

, 2022
Long non-coding RNAs (lncRNAs) are reported to play an important regulatory effect in carcinogenesis and malignancy. We found by high-throughput sequencing that LINC01615 is upregulated in breast cancer patients and reduces patients’ overall ...
Yuan Xiang, Jiapeng Li, Liu, Yuhuan, Yuhuan Liu, Hui Liu, Li, Jiapeng, Liao, Xinghua, Xinghua Liao, Su, Li, Xiang, Yuan, Feng, Lingyun, Li Su, Liu, Hui, Lingyun Feng   +13 more
core   +1 more source

Bcl-2 expression is a poor predictor for hepatocellular carcinoma prognosis of andropause-age patients

Cancer Biology & Medicine, 2016
Objective: The expression of B-cell lymphoma 2 (Bcl-2) seems to be influenced by the endocrine environment. Numerous reports demonstrate the diverse expression of Bcl-2 family members under sex steroid regulation.
Xiao-Fei Zhang, Xin Yang, Hu-Liang Jia, Wen-Wei Zhu, Lu Lu, Wei Shi, Hao Zhang, Jin-Hong Chen, Yi-Feng Tao, Zheng-Xin Wang, Jun Yang, Lian-Xin Wang, Ming Lu, Yan Zheng, Jing Zhao, Qiong-Zhu Dong, Lun-Xiu Qin   +16 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer [PDF]

, 2013
<p>Background: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)–extracellular signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a number of tumour types including prostate cancer (CaP). The mechanism
Kalna, G., Yang, Z H, Z H Yang, Leung, H.Y., Scardino, P, L B Singh, Singh, LB, H Møller, C Cooper, Cuzick, J, J Fleming, Singh, L.B., Yang, Z.H., I Ahmad, G Kalna, D M Berney, Singh, L. B., Scardino, P., Leung, H Y, Ahmad, I., Møller, H; id_orcid, J Cuzick, Berney, D. M., Cuzick, J., Møller, H., Leung, H. Y., Berney, DM, Fisher, G., Fleming, J., Cooper, C., Leung, HY, Kalna, G, P Scardino, Yang, Z. H., Berney, D.M., Fisher, G, Cooper, C, Møller, H, Ahmad, I, G Fisher, Yang, ZH, Singh, L B, Fleming, J, H Y Leung, Berney, D M   +44 more
core   +1 more source