Results 91 to 100 of about 1,024,518 (204)

A Hierarchical Probability Model of Colon Cancer [PDF]

, 2010
We consider a model of fixed size $N = 2^l$ in which there are $l$ generations of daughter cells and a stem cell. In each generation $i$ there are $2^{i-1}$ daughter cells.
Kelly, Michael
core  

How Does Multistep Tumorigenesis Really Proceed? [PDF]

, 2018
Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate biologic mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state.
Chaffer, Christine L., Weinberg, Robert A   +1 more
core   +1 more source

Frequency and Implications of High‐Risk Pharmacogenomic Phenotypes Identified in a Diverse Australian Pediatric Oncology Cohort

Clinical and Translational Science
Pharmacogenomics remains underutilized in pediatric oncology, despite the existence of evidence‐based guidelines. Implementation of pharmacogenomics‐informed prescribing could improve medication safety and efficacy in pediatric oncology patients, who are
Claire Moore, Andreas Halman, Tayla Stenta, Dhrita Khatri, Elizabeth Williams, Roxanne Dyas, Julian Stolper, David A. Elliott, Rachel Conyers   +8 more
doaj   +1 more source

Steroid-Refractory Acute GVHD: Predictors and Outcomes

Advances in Hematology, 2011
Patients with steroid-resistant acute graft versus host disease (aGVHD) have a dismal prognosis, with mortality rates in excess of 90%. We sought to identify a subgroup of patients less likely to benefit from initial therapy with corticosteroids as well
Jason R. Westin, Rima M. Saliba, Marcos De Lima, Amin Alousi, Chitra Hosing, Muzaffar H. Qazilbash, Issa F. Khouri, Elizabeth J. Shpall, Paolo Anderlini, Gabriela Rondon, Borje S. Andersson, Richard Champlin, Daniel R. Couriel   +12 more
doaj   +1 more source

Transcriptional landscape of neuronal and cancer stem cells [PDF]

, 2013
Tumor mass is composed by heterogeneous cell population including a subset of “cancer stem cells” (CSC). Oncogenic signals foster CSC by transforming tissue stem cells or by reprogramming progenitor/differentiated cells towards stemness.
Miele, Evelina
core  

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. [PDF]

, 2017
Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient ...
A Ootani, A Ralston, A Roostaee, AG Muntean, Aimee Flores, B Ohlstein, B-Z Chen, C Moolenbeek, C Stringari, C Yang, CA Micchelli, CA Micchelli, Carl S. Thummel, CCP Aires, Christian S. Earl, Claire Bensard, D Dutta, D Karolchik, Dean Y. Li, DK Bricker, Don Delker, Dona R. Wisidagama, E Berger, F Cao, H Jiang, H Li, H Li, H Tateno, Heather R. Christofk, Helong Zhao, I Martínez-Reyes, J Benavides, J Wang, J Wang, James E. Cox, Jared Rutter, Jason Tanner, JC Schell, Jeffrey Mohlman, JL Golob, John C. Schell, JS Wu, K Birsoy, K Ito, K Nishino, K Weber, Kristofor A. Olson, KT Pate, KW McCool, LB Sullivan, Lei Jiang, Lise K. Sorensen, LK Boroughs, LR Edmunds, LR Gray, M Uhlen, M Uhlen, MA Keller, Mary P. Bronner, MB Gerstein, MJ Dailey, MJ Rodríguez-Colman, N Barker, N Buchon, NM Vacanti, O Warburg, PA Vigueira, Peng Wei, Priyanka Kanth, R Camarda, Ralph J. DeBerardinis, RB Flavell, Ren Miao, RW Daniels, S Beyaz, S Herzig, S Simmini, T Bender, T Sato, T Sato, T Sato, T Simsek, T. Cameron Waller, William E. Lowry, X Yin, X-M Wang, Y-Y Fan   +86 more
core   +1 more source

Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness

Signal Transduction and Targeted Therapy
Psychological stress causes gut microbial dysbiosis and cancer progression, yet how gut microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that psychological stress promotes breast tumor growth and cancer
Bai Cui, Huandong Luo, Bin He, Xinyu Liu, Dekang Lv, Xiaoyu Zhang, Keyu Su, Sijia Zheng, Jinxin Lu, Cenxin Wang, Yuqing Yang, Zhuoran Zhao, Xianxian Liu, Xu Wang, Yingrui Zhao, Xiaoshan Nie, Yuanyuan Jiang, Ziyu Zhang, Congcong Liu, Xinyi Chen, Anqi Cai, Zhumeng Lv, Zhihang Liu, Fan An, Yunkun Zhang, Qiulong Yan, Keith W. Kelley, Guowang Xu, Lingzhi Xu, Quentin Liu, Fei Peng   +30 more
doaj   +1 more source

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? [PDF]

, 2018
Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self-renew and to generate large populations of more differentiated descendants.
Scheel, Christina, Weinberg, Robert A
core   +1 more source

Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]

, 2017
The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca, Bicciato, Silvio, Cappuzzello, Elisa, Del Sal, Giannino, Forcato, Mattia, Ingallina, Eleonora, Mano, Miguel, Marotta, Carolina, Neri, Carmelo, Rosato, Antonio, Ruggeri, Naomi, Sorrentino, Giovanni, Zannini, Alessandro   +12 more
core   +3 more sources

Ex vivo expansion in a clinical grade medium, containing growth factors from human platelets, enhances migration capacity of adipose stem cells

Frontiers in Immunology
IntroductionAdipose tissue mesenchymal stem/stromal cells (ASC) can be used as advanced therapy medicinal product in regenerative and cancer medicine.
Francesco Agostini, Carla Vicinanza, Elisabetta Lombardi, Francesco Da Ros, Miriam Marangon, Samuele Massarut, Mario Mazzucato, Cristina Durante   +7 more
doaj   +1 more source