Results 81 to 90 of about 1,024,518 (204)

Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

Cell Death and Disease, 2023
Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui, Bin He, Yanping Huang, Cenxin Wang, Huandong Luo, Jinxin Lu, Keyu Su, Xiaoyu Zhang, Yuanyuan Luo, Zhuoran Zhao, Yuqing Yang, Yunkun Zhang, Fan An, Hong Wang, Eric W.-F. Lam, Keith W. Kelley, Ling Wang, Quentin Liu, Fei Peng   +18 more
doaj   +1 more source

Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells [PDF]

, 2016
BACKGROUND: Cancer stem cells contribute to tumor initiation, heterogeneity, and recurrence, and are critical targets in cancer therapy. Sprouty4 (Spry4) is a potent inhibitor of signal transduction pathways elicited by receptor tyrosine kinases, and has
Calvin Vary, Hongyu Jing, Lucy Liaw, Robert Friesel, Shucheng Hua, Xuehui Yang   +5 more
core   +1 more source

Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells

Cancer Communications, 2018
Background Breast cancer stem cells (BCSCs) are considered responsible for cancer relapse and drug resistance. Understanding the identity of BCSCs may open new avenues in breast cancer therapy.
Mengying Tong, Ziqian Deng, Mengying Yang, Chang Xu, Xiaolong Zhang, Qingzheng Zhang, Yuwei Liao, Xiaodi Deng, Dekang Lv, Xuehong Zhang, Yu Zhang, Peiying Li, Luyao Song, Bicheng Wang, Aisha Al-Dherasi, Zhiguang Li, Quentin Liu   +16 more
doaj   +1 more source

A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem-like Cells in S/G(2)/M Phases [PDF]

, 2013
Purpose: Because chemoradiotherapy selectively targets proliferating cancer cells, quiescent cancer stem-like cells are resistant. Mobilization of the cell cycle in quiescent leukemia stem cells sensitizes them to cell death signals.
Fujiwara, Toshiyoshi, Hashimoto, Yuuri, Hoffman, Robert M., Kagawa, Shunsuke, Kishimoto, Hiroyuki, Kuroda, Shinji, Nagasaka, Takeshi, Nishizaki, Masahiko, Shirakawa, Yasuhiro, Tazawa, Hiroshi, Uno, Futoshi, Urata, Yasuo, Yano, Shuya   +12 more
core   +1 more source

MicroRNAs, stem cells and cancer stem cells

World Journal of Stem Cells, 2012
This review discusses the various regulatory characteristics of microRNAs that are capable of generating widespread changes in gene expression via post translational repression of many mRNA targets and control self-renewal, differentiation and division of cells.
openaire   +2 more sources

LMO7-mediated POLR2A degradation promotes cellular senescence through the MDM4/p53/p21 axis

Cell Death and Disease
As the largest subunit of RNA polymerase II, POLR2A plays an irreplaceable role in gene expression, with the regulation of its own expression and physiological function having attracted widespread attention.
Chutong Lai, Wen Fu, Jiaxin Liu, Shuai Hou, Jinsong Yan, Haixin Lei   +5 more
doaj   +1 more source

Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma

Biology Direct
Members from the RAS GTPase superfamily have been closely implicated in the tumorigenesis of various human cancers. Recent sequencing analysis of lung adenocarcinoma has revealed the prevalence of alterations in the RIT1 gene that is a close RAS paralog.
Ruilan Ma, Dian Yang, Peng Wang, Ziyi Zhang, Xuehong Zhang, Jialiang Song, Han Liu, Shuyan Liu, Yingqiu Zhang, Lijuan Zou   +9 more
doaj   +1 more source

Generation and trapping of a mesoderm biased state of human pluripotency

Nature Communications, 2020
Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias by ...
Dylan Stavish, Charlotta Böiers, Christopher Price, Thomas J. R. Frith, Jason Halliwell, Ingrid Saldaña-Guerrero, Jason Wray, John Brown, Jonathon Carr, Chela James, Ivana Barbaric, Peter W. Andrews, Tariq Enver   +12 more
doaj   +1 more source

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources

Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation

Genome Medicine, 2020
Background Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have ...
Shiyang Liu, Nathan Harmston, Trudy Lee Glaser, Yunka Wong, Zheng Zhong, Babita Madan, David M. Virshup, Enrico Petretto   +7 more
doaj   +1 more source