CellsDauricine has been shown to possess intriguing anti-cancerous activities against various malignancies. The current study examined the inhibitory effects of dauricine against lung adenocarcinoma with cell lines and animal models.
Waleed Yousuf +13 more
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DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance
Nature Communications, 2022 DNA is well-documented to stimulate immune response. Here the authors show that the activation of cyclic GMP-AMP synthase (cGAS) depends on DNA mechanical flexibility, itself determined by DNA-sequence, damage and length.
Lina Wang +11 more
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Encapsulated stem cells for cancer therapy [PDF]
, 2014 Stem cells have inherent tumor‑trophic migratory properties and can serve as vehicles for delivering effective, targeted therapy to isolated tumors and metastatic disease, making them promising anti‑cancer agents.
Shah, Khalid
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Urothelial Cancer Stem Cells [PDF]
The Scientific World JOURNAL, 2010 There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to conventional antitumor therapy.
Irena Dimov +2 more
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APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression
BMC Cancer, 2019 Background Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of Adenomatous polyposis coli 2 (APC2),
Noha-Ehssan Mohamed +4 more
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The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology [PDF]
, 2010 The cancer stem cell theory entails the existence of a hierarchically organized, rare population of cells which are responsible for tumor initiation, self-renewal/maintenance, and mutation accumulation.
Alberto M. Martelli +17 more
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Cancer, stem cell misplacement and cancer stem cells
Journal of Cellular and Molecular Medicine, 2013 AbstractThe cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi‐stage carcinogenesis of breast cancer and proposed that ‘Invasive cancers are not necessary from preformed in situ tumours—an alternative way of carcinogenesis ...
openaire +2 more sources
eLife, 2016 Genetic alterations which impair the function of the TP53 signaling pathway in TP53 wild-type human tumors remain elusive. To identify new components of this pathway, we performed a screen for genes whose loss-of-function debilitated TP53 signaling and ...
Shi Yun Yeo +11 more
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RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation
Breast Cancer Research, 2022 Epithelial-to-mesenchymal transition (EMT) is a critical underpinning process for cancer progression, recurrence and resistance to drug treatment. Identification of new regulators of EMT could lead to the development of effective therapies to improve the
Subbulakshmi Karthikeyan +2 more
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Cancer stem cells display extremely large evolvability alternating plastic and rigid networks as a potential mechanism Network models, novel therapeutic target strategies, and the contributions of hypoxia, inflammation and cellular senescence [PDF]
, 2015 Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by a decrease of plasticity at late
Achuthan +135 more
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