Results 61 to 70 of about 1,024,518 (204)
Cell Reports, 2015 The clinical applicability of direct cell fate conversion depends on obtaining tissue from patients that is easy to harvest, store, and manipulate for reprogramming.
Jong-Hee Lee +11 more
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Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells [PDF]
, 2010 Background Since the first suggestion of prospectively identifiable cancer stem cells in solid tumors, efforts have been made to characterize reported cancer stem cell surrogates in existing cancer cell lines, and cell lines rich with these ...
Bisrat G Debeb +17 more
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Breast Cancer Stem Cells [PDF]
Biomedicines, 2018 Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality ...
Judy S. Crabtree, Lucio Miele
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Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]
, 2016 The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela +10 more
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Prostate cancer stem cells [PDF]
The Journal of Pathology, 2008 AbstractDespite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone‐refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell‐like cells coexisting within a heterogeneous tumour mass ...
Lang, SH, Frame, FM, Collins, AT
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Journal of Experimental & Clinical Cancer Research, 2018 Background The PD-L1/PD-1 pathway blockade-mediated immune therapy has shown promising efficacy in the treatment of multiple cancers including melanoma. The present study investigated the effects of the flavonoid apigenin on the PD-L1 expression and the ...
Lu Xu +15 more
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Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma
Nature Communications, 2023 The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials.
Jing Hao +8 more
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Overexpression of Large-Conductance Calcium-Activated Potassium Channels in Human Glioblastoma Stem-Like Cells and Their Role in Cell Migration [PDF]
, 2017 Glioblastomas (GBMs) are brain tumors characterized by diffuse invasion of cancer cells into the healthy brain parenchyma, and establishment of secondary foci. GBM cells abundantly express large-conductance, calcium-activated potassium (BK) channels that
Abdullaev +49 more
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International Journal of Hepatology, 2011 Hepatocellular carcinoma is the most common primary malignancy of the liver in adults. It is also the fifth most common solid cancer worldwide and the third leading cause of cancer-related death. Recent research supports that liver cancer is a disease of adult stem cells. From the models of experimental hepatocarcinogenesis, there may be at least three
Sameh Mikhail, Aiwu Ruth He
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Experimental Biology and Medicine, 2021 Being the second leading cause of death globally, cancer has been a long-standing and rapidly evolving focus of biomedical research and practice in the world. A tremendous effort has been made to understand the origin of cancer cells, the formation of cancerous tissues, and the mechanism by which they spread and relapse, but the disease still remains ...
Wen Yin +3 more
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