Results 41 to 50 of about 596,466 (219)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

eLife, 2016
Genetic alterations which impair the function of the TP53 signaling pathway in TP53 wild-type human tumors remain elusive. To identify new components of this pathway, we performed a screen for genes whose loss-of-function debilitated TP53 signaling and ...
Shi Yun Yeo, Yoko Itahana, Alvin Kunyao Guo, Rachel Han, Kozue Iwamoto, Hung Thanh Nguyen, Yi Bao, Kai Kleiber, Ya Jun Wu, Boon Huat Bay, Mathijs Voorhoeve, Koji Itahana   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

Cell Death and Disease, 2023
Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui, Bin He, Yanping Huang, Cenxin Wang, Huandong Luo, Jinxin Lu, Keyu Su, Xiaoyu Zhang, Yuanyuan Luo, Zhuoran Zhao, Yuqing Yang, Yunkun Zhang, Fan An, Hong Wang, Eric W.-F. Lam, Keith W. Kelley, Ling Wang, Quentin Liu, Fei Peng   +18 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

LMO7-mediated POLR2A degradation promotes cellular senescence through the MDM4/p53/p21 axis

Cell Death and Disease
As the largest subunit of RNA polymerase II, POLR2A plays an irreplaceable role in gene expression, with the regulation of its own expression and physiological function having attracted widespread attention.
Chutong Lai, Wen Fu, Jiaxin Liu, Shuai Hou, Jinsong Yan, Haixin Lei   +5 more
doaj   +1 more source

Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells

Cancer Communications, 2018
Background Breast cancer stem cells (BCSCs) are considered responsible for cancer relapse and drug resistance. Understanding the identity of BCSCs may open new avenues in breast cancer therapy.
Mengying Tong, Ziqian Deng, Mengying Yang, Chang Xu, Xiaolong Zhang, Qingzheng Zhang, Yuwei Liao, Xiaodi Deng, Dekang Lv, Xuehong Zhang, Yu Zhang, Peiying Li, Luyao Song, Bicheng Wang, Aisha Al-Dherasi, Zhiguang Li, Quentin Liu   +16 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma

Biology Direct
Members from the RAS GTPase superfamily have been closely implicated in the tumorigenesis of various human cancers. Recent sequencing analysis of lung adenocarcinoma has revealed the prevalence of alterations in the RIT1 gene that is a close RAS paralog.
Ruilan Ma, Dian Yang, Peng Wang, Ziyi Zhang, Xuehong Zhang, Jialiang Song, Han Liu, Shuyan Liu, Yingqiu Zhang, Lijuan Zou   +9 more
doaj   +1 more source