Results 21 to 30 of about 1,024,518 (204)

PTEN, Stem Cells, and Cancer Stem Cells [PDF]

Journal of Biological Chemistry, 2009
Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with ...
Reginald, Hill, Hong, Wu
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Prostate Stem Cells and Cancer Stem Cells [PDF]

Cold Spring Harbor Perspectives in Medicine, 2018
Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as
Jia J, Li, Michael M, Shen
openaire   +2 more sources

The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]

, 2017
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio, García Heredia, José Manuel, Lucena Cacace, Antonio, Pérez, Marco, Verdugo Sivianes, Eva María   +4 more
core   +1 more source

Breast cancer stem cells [PDF]

Frontiers in Physiology, 2013
Cancer metastasis, resistance to therapies and disease recurrence are significant hurdles to successful treatment of breast cancer. Identifying mechanisms by which cancer spreads, survives treatment regimes and regenerates more aggressive tumors are critical to improving patient survival.
Owens, Thomas W., Naylor, Matthew J.
openaire   +3 more sources

Mutasi Gen p53: Faktor Prediktif Kanker Payudara?

Indonesian Journal of Cancer, 2008
Farmakogenetik dalam terapi kanker adalah pemberian terapi kepada pasien berdasarkan status atau profil genetik dari sel kanker. Dengan demikian, pemberian kemoterapi diharapkan bisa lebih efektif dan meningkatkan kualitas hidup pasien dengan menghindari
Putri Y. Suyanto, Ahmad R. Utomo, Ferry Sandra   +2 more
doaj   +1 more source

RBM4 regulates cellular senescence via miR1244/SERPINE1 axis

Cell Death and Disease, 2023
Cellular senescence serves as a powerful tumor suppressing mechanism that inhibits the proliferation of cancer cells bearing oncogenic mutations at the initial stage of cancer development.
Luning Wang, Xiaohong Zhang, Junxiu Sheng, Lei Chen, Lili Zhi, Qianqian Zheng, Yangfan Qi, Linlin Wang, Jinrui Zhang, Jinyao Zhao, Yang Wang, Shu-Xin Liu, Ming-Zhong Sun, Wenjing Zhang   +13 more
doaj   +1 more source

Lack of correlation of stem cell markers in breast cancer stem cells [PDF]

, 2014
BACKGROUND: Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
A M Thompson, AM Thompson, C Calabrese, C Ginestier, C Scheel, C Sheridan, CE Eyler, CL Chaffer, CM Fillmore, E Charafe-Jauffret, E Resetkova, EY Tan, F Vaillant, G Farnie, G Kristiansen, G Rappa, H Harrison, H Korkaya, J Stingl, J Zhou, JC Lawson, JM Rosen, K Engelmann, K He, K Murray, M Al-Hajj, M Boylan, M Christgen, M Kok, M Pajic, M V Appleyard, MA Ahmed, ME Prince, MH Wright, MJ Grimshaw, MV Appleyard, O Al-Assar, O Leis, O Moussa, P J Coates, P Kabos, R Nenutil, S Bao, S Liu, SY Kim, SY Park, T Tanei, TM Phillips, WW Hwang-Verslues, Y Liu   +49 more
core   +4 more sources

Efek Mutasi K-RAS pada Kanker Kolorektal terhadap Terapi Antibodi Monoklonal anti EGFR

Indonesian Journal of Cancer, 2008
Kanker kolorektal merupakan salah satu jenis kanker yang banyak diderita oleh masyarakat dan dapat disembuhkan jika terdeteksi dini. Salah satu penyebab kanker adalah terjadinya mutasi pada gen-gen tertentu.
Farid Sastra Nagara, Ahmad R. Utomo, Ferry Sandra   +2 more
doaj   +1 more source

Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells. [PDF]

, 2018
The goal of anticancer therapy is to selectively eradicate all malignant cells. Unfortunately for the majority of patients with metastatic disease, this goal is consistently thwarted by the nearly inevitable development of therapeutic resistance; the ...
Cabrales, Pedro, Caroen, Scott, Carter, Corey A, Oronsky, Arnold, Oronsky, Bryan, Reid, Tony R   +5 more
core   +2 more sources

Cancer stem cell metabolism [PDF]

Breast Cancer Research, 2016
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy.
Peiris-Pagès, M, Martinez-Outschoorn, U, Pestell, R, Sotgia, F, Lisanti, MP   +4 more
openaire   +3 more sources