Results 1 to 10 of about 596,466 (219)

Collagen Type I Induces a Balance in the Expression of Anti- and Pro-Apoptotic Genes in Hepatocellular Carcinoma Cells [PDF]

Middle East Journal of Cancer, 2022
Background: The importance of extracellular matrix (ECM) components in the progression of hepatocellular carcinoma (HCC) has been shown in many studies. Although restoring or activating apoptosis in tumors is an active area of cancer research, little is ...
Yaprak Donmez Cakil, Zeynep Akbulut, Hatice Maras, Damla Gokceoglu Kayali, Ranan Gulhan Aktas   +4 more
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Construction of a microenvironment immune gene model for predicting the prognosis of endometrial cancer

BMC Cancer, 2021
Background Infiltrating immune and stromal cells are important components of the endometrial cancer (EC) microenvironment, which has a significant effect on the biological behavior of EC, suggesting that unique immune-related genes may be associated with
Yichen Wang, Jingkai Zhang, Yijun Zhou, Zhiguang Li, Dekang Lv, Quentin Liu   +5 more
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Sp1 induced gene TIMP1 is related to immune cell infiltration in glioblastoma

Scientific Reports, 2022
Tumor immune microenvironment exerts a profound effect on the population of infiltrating immune cells. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is frequently overexpressed in a variety of cells, particularly during inflammation and tissue ...
Lu Liu, Shuyao Yang, Kefeng Lin, Xiaoman Yu, Jiaqi Meng, Chao Ma, Zheng Wu, Yuchao Hao, Ning Chen, Qi Ge, Wenli Gao, Xiang Wang, Eric W.-F. Lam, Lin Zhang, Fangcheng Li, Bilian Jin, Di Jin   +16 more
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Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

Signal Transduction and Targeted Therapy, 2022
Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown.
SiSi Li, YangFan Qi, JiaChuan Yu, YuChao Hao, Bin He, MengJuan Zhang, ZhenWei Dai, TongHui Jiang, SuYi Li, Fang Huang, Ning Chen, Jing Wang, MengYing Yang, DaPeng Liang, Fan An, JinYao Zhao, WenJun Fan, YuJia Pan, ZiQian Deng, YuanYuan Luo, Tao Guo, Fei Peng, ZhiJie Hou, ChunLi Wang, FeiMeng Zheng, LingZhi Xu, Jie Xu, QingPing Wen, BiLian Jin, Yang Wang, Quentin Liu   +30 more
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Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

eLife, 2021
Targeting DNA repair pathway offers an important therapeutic strategy for Homo sapiens (human) cancers. However, the failure of DNA repair inhibitors to markedly benefit patients necessitates the development of new strategies.
Qiaoling Liu, Qi Xiao, Zhen Sun, Bo Wang, Lina Wang, Na Wang, Kai Wang, Chengli Song, Qingkai Yang   +8 more
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Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

Cell Communication and Signaling, 2019
Background ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of ErbB2 are regulated dynamically by ...
Jinrui Zhang, Qiong Li, Yueguang Wu, Duchuang Wang, Lu Xu, Yang Zhang, Shanshan Wang, Taishu Wang, Fang Liu, Mohamed Y. Zaky, Shuai Hou, Shuyan Liu, Kun Zou, Haixin Lei, Lijuan Zou, Yingqiu Zhang, Han Liu   +16 more
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Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer

Genome Biology, 2021
Background Deregulated gene expression is a hallmark of cancer; however, most studies to date have analyzed short-read RNA sequencing data with inherent limitations.
Kie Kyon Huang, Jiawen Huang, Jeanie Kar Leng Wu, Minghui Lee, Su Ting Tay, Vikrant Kumar, Kalpana Ramnarayanan, Nisha Padmanabhan, Chang Xu, Angie Lay Keng Tan, Charlene Chan, Dennis Kappei, Jonathan Göke, Patrick Tan   +13 more
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RBM4 regulates cellular senescence via miR1244/SERPINE1 axis

Cell Death and Disease, 2023
Cellular senescence serves as a powerful tumor suppressing mechanism that inhibits the proliferation of cancer cells bearing oncogenic mutations at the initial stage of cancer development.
Luning Wang, Xiaohong Zhang, Junxiu Sheng, Lei Chen, Lili Zhi, Qianqian Zheng, Yangfan Qi, Linlin Wang, Jinrui Zhang, Jinyao Zhao, Yang Wang, Shu-Xin Liu, Ming-Zhong Sun, Wenjing Zhang   +13 more
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Conflicts of CpG density and DNA methylation are proximally and distally involved in gene regulation in human and mouse tissues

Epigenetics, 2018
The relationship between CpG content and DNA methylation has attracted considerable interest in recent years. Direct or indirect methods have been developed to investigate their regulatory functions based on various hypotheses, large cohort studies, and ...
Fushun Chen, Qingzheng Zhang, Xiaodi Deng, Xia Zhang, Chengjun Chen, Dekang Lv, Yulong Li, Dan Li, Yu Zhang, Peiying Li, Yunpeng Diao, Lan Kang, Gareth I. Owen, Jun Chen, Zhiguang Li   +14 more
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Standardization of platelet releasate products for clinical applications in cell therapy: a mathematical approach

Journal of Translational Medicine, 2017
Background Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for cell expansion but such products are characterized by undesired variability ...
Francesco Agostini, Jerry Polesel, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Alessandro Da Ponte, Giuseppe Astori, Cristina Durante, Mario Mazzucato   +8 more
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