Results 1 to 10 of about 1,024,518 (204)

Collagen Type I Induces a Balance in the Expression of Anti- and Pro-Apoptotic Genes in Hepatocellular Carcinoma Cells [PDF]

Middle East Journal of Cancer, 2022
Background: The importance of extracellular matrix (ECM) components in the progression of hepatocellular carcinoma (HCC) has been shown in many studies. Although restoring or activating apoptosis in tumors is an active area of cancer research, little is ...
Yaprak Donmez Cakil, Zeynep Akbulut, Hatice Maras, Damla Gokceoglu Kayali, Ranan Gulhan Aktas   +4 more
doaj   +1 more source

Construction of a microenvironment immune gene model for predicting the prognosis of endometrial cancer

BMC Cancer, 2021
Background Infiltrating immune and stromal cells are important components of the endometrial cancer (EC) microenvironment, which has a significant effect on the biological behavior of EC, suggesting that unique immune-related genes may be associated with
Yichen Wang, Jingkai Zhang, Yijun Zhou, Zhiguang Li, Dekang Lv, Quentin Liu   +5 more
doaj   +1 more source

Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers [PDF]

, 2013
Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that are maintained by a small population of undifferentiated long-lived ...
Gutenkunst, Ryan N., Jilkine, Alexandra
core   +5 more sources

Sp1 induced gene TIMP1 is related to immune cell infiltration in glioblastoma

Scientific Reports, 2022
Tumor immune microenvironment exerts a profound effect on the population of infiltrating immune cells. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is frequently overexpressed in a variety of cells, particularly during inflammation and tissue ...
Lu Liu, Shuyao Yang, Kefeng Lin, Xiaoman Yu, Jiaqi Meng, Chao Ma, Zheng Wu, Yuchao Hao, Ning Chen, Qi Ge, Wenli Gao, Xiang Wang, Eric W.-F. Lam, Lin Zhang, Fangcheng Li, Bilian Jin, Di Jin   +16 more
doaj   +1 more source

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. [PDF]

, 2016
The epithelial-mesenchymal transition (EMT) endows carcinoma cells with phenotypic plasticity that can facilitate the formation of cancer stem cells (CSCs) and contribute to the metastatic cascade.
Banno, Asoka, Bui, Jack D, Chang, Aaron N, Chang, John T, Fisch, Kathleen, Florea, Bogdan I, Garcia, Daniel A, Geurink, Paul P, Kim, Stephanie H, Lopez, Justine, Metz, Patrick J, Ovaa, Huib, Overkleeft, Hermen S, van Baarsel, Eric D, Widjaja, Christella E, Yang, Jing   +15 more
core   +10 more sources

Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

Signal Transduction and Targeted Therapy, 2022
Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown.
SiSi Li, YangFan Qi, JiaChuan Yu, YuChao Hao, Bin He, MengJuan Zhang, ZhenWei Dai, TongHui Jiang, SuYi Li, Fang Huang, Ning Chen, Jing Wang, MengYing Yang, DaPeng Liang, Fan An, JinYao Zhao, WenJun Fan, YuJia Pan, ZiQian Deng, YuanYuan Luo, Tao Guo, Fei Peng, ZhiJie Hou, ChunLi Wang, FeiMeng Zheng, LingZhi Xu, Jie Xu, QingPing Wen, BiLian Jin, Yang Wang, Quentin Liu   +30 more
doaj   +1 more source

Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

eLife, 2021
Targeting DNA repair pathway offers an important therapeutic strategy for Homo sapiens (human) cancers. However, the failure of DNA repair inhibitors to markedly benefit patients necessitates the development of new strategies.
Qiaoling Liu, Qi Xiao, Zhen Sun, Bo Wang, Lina Wang, Na Wang, Kai Wang, Chengli Song, Qingkai Yang   +8 more
doaj   +1 more source

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
core   +1 more source

Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

Cell Communication and Signaling, 2019
Background ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of ErbB2 are regulated dynamically by ...
Jinrui Zhang, Qiong Li, Yueguang Wu, Duchuang Wang, Lu Xu, Yang Zhang, Shanshan Wang, Taishu Wang, Fang Liu, Mohamed Y. Zaky, Shuai Hou, Shuyan Liu, Kun Zou, Haixin Lei, Lijuan Zou, Yingqiu Zhang, Han Liu   +16 more
doaj   +1 more source