Results 31 to 40 of about 596,466 (219)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Dauricine Impedes the Tumorigenesis of Lung Adenocarcinoma by Regulating Nrf2 and Reactive Oxygen Species

Cells
Dauricine has been shown to possess intriguing anti-cancerous activities against various malignancies. The current study examined the inhibitory effects of dauricine against lung adenocarcinoma with cell lines and animal models.
Waleed Yousuf, Nimra Zafar Siddiqui, Perbhat Ali, Shaoxuan Cheng, Immad Ansari, Jialiang Song, Minghe Dai, Zhiyuan Qiu, Yue Zhu, Yaowen Zhang, Shuyan Liu, Yingqiu Zhang, Zhenhua Liu, Han Liu   +13 more
doaj   +1 more source

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

Journal of Experimental & Clinical Cancer Research, 2018
Background The PD-L1/PD-1 pathway blockade-mediated immune therapy has shown promising efficacy in the treatment of multiple cancers including melanoma. The present study investigated the effects of the flavonoid apigenin on the PD-L1 expression and the ...
Lu Xu, Yang Zhang, Kang Tian, Xi Chen, Rongxin Zhang, Xindi Mu, Yueguang Wu, Duchuang Wang, Shanshan Wang, Fang Liu, Taishu Wang, Jinrui Zhang, Shuyan Liu, Yingqiu Zhang, Caixia Tu, Han Liu   +15 more
doaj   +1 more source

Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma

Nature Communications, 2023
The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials.
Jing Hao, Xiangzi Han, Haidong Huang, Xingjiang Yu, Jiankang Fang, Jianjun Zhao, Richard A. Prayson, Shideng Bao, Jennifer S. Yu   +8 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance

Nature Communications, 2022
DNA is well-documented to stimulate immune response. Here the authors show that the activation of cyclic GMP-AMP synthase (cGAS) depends on DNA mechanical flexibility, itself determined by DNA-sequence, damage and length.
Lina Wang, Siru Li, Kai Wang, Na Wang, Qiaoling Liu, Zhen Sun, Li Wang, Lulu Wang, Quentin Liu, Chengli Song, Caigang Liu, Qingkai Yang   +11 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression

BMC Cancer, 2019
Background Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of Adenomatous polyposis coli 2 (APC2),
Noha-Ehssan Mohamed, Trevor Hay, Karen R. Reed, Matthew J. Smalley, Alan R. Clarke   +4 more
doaj   +1 more source

RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation

Breast Cancer Research, 2022
Epithelial-to-mesenchymal transition (EMT) is a critical underpinning process for cancer progression, recurrence and resistance to drug treatment. Identification of new regulators of EMT could lead to the development of effective therapies to improve the
Subbulakshmi Karthikeyan, Patrick J. Casey, Mei Wang   +2 more
doaj   +1 more source