Results 51 to 60 of about 533,069 (264)
eJHaem, 2021 Recent advances in treatment options for multiple myeloma (MM) have positive impact on patient survival. However, there is a short fall of rapid and reliable assays that can predict patient response to novel agents.
Martin Grundy +5 more
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Translational Oncology, 2021 Background: Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of diffuse large B cell lymphoma (DLBCL), but the overexpression of multidrug resistance (MDR) transporter proteins, especially P-glycoprotein (P-gp), renders ...
Kaili Liu +11 more
doaj +1 more source
Prostate cancer stem cells [PDF]
The Journal of Pathology, 2008 AbstractDespite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone‐refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell‐like cells coexisting within a heterogeneous tumour mass ...
Lang, SH, Frame, FM, Collins, AT
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson +20 more
wiley +1 more source
A Role for RUNX3 in Inflammation-Induced Expression of IL23A in Gastric Epithelial Cells
Cell Reports, 2014 RUNX3 functions as a tumor suppressor in the gastric epithelium, where its inactivation is frequently observed during carcinogenesis. We identified IL23A as a RUNX3 target gene in gastric epithelial cells.
Yit Teng Hor +7 more
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FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway
Cells, 2021 Over recent years, several Cys2-His2 (C2H2) domain-containing proteins have emerged as critical players in repairing DNA-double strand breaks. Human FLYWCH1 is a newly characterised nuclear transcription factor with (C2H2)-type zinc-finger DNA-binding ...
Sheema Almozyan +3 more
doaj +1 more source
International Journal of Hepatology, 2011 Hepatocellular carcinoma is the most common primary malignancy of the liver in adults. It is also the fifth most common solid cancer worldwide and the third leading cause of cancer-related death. Recent research supports that liver cancer is a disease of adult stem cells. From the models of experimental hepatocarcinogenesis, there may be at least three
Sameh Mikhail, Aiwu Ruth He
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Experimental Biology and Medicine, 2021 Being the second leading cause of death globally, cancer has been a long-standing and rapidly evolving focus of biomedical research and practice in the world. A tremendous effort has been made to understand the origin of cancer cells, the formation of cancerous tissues, and the mechanism by which they spread and relapse, but the disease still remains ...
Wen Yin +3 more
openaire +2 more sources
Nature CommunicationsProteome analysis by data-independent acquisition (DIA) has become a powerful approach to obtain deep proteome coverage, and has gained recent traction for label-free analysis of single cells.
Karl K. Krull +2 more
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Targeting the epigenetic addiction of Merkel cell carcinoma
EMBO Molecular Medicine, 2020 Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine cancer of the skin, with very limited therapeutic options. Although immunotherapy is effective in some cases, there is an unmet need for new therapeutic approaches in MCCs.
Federico Mauri, Cédric Blanpain
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