Results 61 to 70 of about 3,232,837 (206)
Somatic stem cells and the origin of cancer [PDF]
, 2006 Most human cancers derive from a single cell targeted by genetic and epigenetic alterations that initiate malignant transformation. Progressively, these early cancer cells give rise to different generations of daughter cells that accumulate ...
Andreu, E.J. (Enrique José) +2 more
core +1 more source
eJHaem, 2021 Recent advances in treatment options for multiple myeloma (MM) have positive impact on patient survival. However, there is a short fall of rapid and reliable assays that can predict patient response to novel agents.
Martin Grundy +5 more
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Translational Oncology, 2021 Background: Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of diffuse large B cell lymphoma (DLBCL), but the overexpression of multidrug resistance (MDR) transporter proteins, especially P-glycoprotein (P-gp), renders ...
Kaili Liu +11 more
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Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies
Cells, 2019 Recent biomedical discoveries have revolutionized the concept and understanding of carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic, epigenetic, biochemical, and histological changes, with special reference to ...
A. Q. Khan +5 more
semanticscholar +1 more source
The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology [PDF]
, 2010 The cancer stem cell theory entails the existence of a hierarchically organized, rare population of cells which are responsible for tumor initiation, self-renewal/maintenance, and mutation accumulation.
Alberto M. Martelli +17 more
core +2 more sources
A Role for RUNX3 in Inflammation-Induced Expression of IL23A in Gastric Epithelial Cells
Cell Reports, 2014 RUNX3 functions as a tumor suppressor in the gastric epithelium, where its inactivation is frequently observed during carcinogenesis. We identified IL23A as a RUNX3 target gene in gastric epithelial cells.
Yit Teng Hor +7 more
doaj +1 more source
FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway
Cells, 2021 Over recent years, several Cys2-His2 (C2H2) domain-containing proteins have emerged as critical players in repairing DNA-double strand breaks. Human FLYWCH1 is a newly characterised nuclear transcription factor with (C2H2)-type zinc-finger DNA-binding ...
Sheema Almozyan +3 more
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Role of OCT4 in cancer stem-like cells and chemotherapy resistance.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2020 Cancer stem-like cells (CSCs) contribute to the tumorigenicity, progression, and chemoresistance of cancers. It is not known whether CSCs arise from normal stem cells or if they arise from differentiated cancer cells by acquiring self-renewal features ...
Ismail S. Mohiuddin +2 more
semanticscholar +1 more source
Nature CommunicationsProteome analysis by data-independent acquisition (DIA) has become a powerful approach to obtain deep proteome coverage, and has gained recent traction for label-free analysis of single cells.
Karl K. Krull +2 more
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Targeting the epigenetic addiction of Merkel cell carcinoma
EMBO Molecular Medicine, 2020 Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine cancer of the skin, with very limited therapeutic options. Although immunotherapy is effective in some cases, there is an unmet need for new therapeutic approaches in MCCs.
Federico Mauri, Cédric Blanpain
doaj +1 more source