Cancer systems biology: a network modeling perspective [PDF]
Carcinogenesis, 2009 Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell type and tissue origin but also as a disease involving dysregulation of multiple pathways governing fundamental cell processes such as death, proliferation ...
Kreeger, Pamela K. +1 more
core +9 more sources
CRA toolbox: software package for conditional robustness analysis of cancer systems biology models in MATLAB. [PDF]
BMC Bioinformatics, 2019 In cancer research, robustness of a complex biochemical network is one of the most relevant properties to investigate for the development of novel targeted therapies.
Bianconi F +3 more
europepmc +2 more sources
Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB). [PDF]
BMC Bioinformatics, 2018 Recent cancer genome studies on many human cancer types have relied on multiple molecular high-throughput technologies. Given the vast amount of data that has been generated, there are surprisingly few databases which facilitate access to these data and ...
Krempel R +5 more
europepmc +2 more sources
Systems biology and cancer, [Editorial] [PDF]
Progress in Biophysics and Molecular Biology, 2011 The systems approach to complex biological problems has rapidly gained ground during the first decade of this century. There are several reasons for this development. An important one is that while the achievement of sequencing the complete human genome,
Ana M. Soto +25 more
core +6 more sources
Systems Biology and Experimental Model Systems of Cancer [PDF]
Journal of Personalized Medicine, 2020 Over the past decade, we have witnessed an increasing number of large-scale studies that have provided multi-omics data by high-throughput sequencing approaches.
Gizem Damla Yalcin +3 more
semanticscholar +5 more sources
Conditional robustness analysis for fragility discovery and target identification in biochemical networks and in cancer systems biology. [PDF]
BMC Syst Biol, 2015 BackgroundThe study of cancer therapy is a key issue in the field of oncology research and the development of target therapies is one of the main problems currently under investigation.
Bianconi F +5 more
europepmc +2 more sources
Cancer systems biology in the genome sequencing era: Part 1, dissecting and modeling of tumor clones and their networks [PDF]
Seminars in Cancer Biology, 2014 Recent tumor genome sequencing confirmed that one tumor often consists of multiple cell subpopulations (clones) which bear different, but related, genetic profiles such as mutation and copy number variation profiles. Thus far, one tumor has been viewed as a whole entity in cancer functional studies.
E. Wang +5 more
arxiv +3 more sources
Systems Approaches to Cancer Biology [PDF]
Cancer Research, 2016 Abstract Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and ...
Tenley C. Archer +8 more
openalex +5 more sources
Systems Biology of Gastric Cancer: Perspectives on the Omics-Based Diagnosis and Treatment [PDF]
Frontiers in Molecular Biosciences, 2020 Gastric cancer is the fifth most diagnosed cancer in the world, affecting more than a million people and causing nearly 783,000 deaths each year. The prognosis of advanced gastric cancer remains extremely poor despite the use of surgery and adjuvant ...
Ji, Boyang, Shi, Xiao Jing, Wei, Yongjun
core +2 more sources
Systems Biology of Cancer Metastasis. [PDF]
Cell Systems, 2019 Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for ...
Yasir Suhail +6 more
semanticscholar +4 more sources