Results 11 to 20 of about 952,815 (316)
Systems biology and cancer, [Editorial] [PDF]
Progress in Biophysics and Molecular Biology, 2011 The systems approach to complex biological problems has rapidly gained ground during the first decade of this century. There are several reasons for this development. An important one is that while the achievement of sequencing the complete human genome,
Maini, Philip +3 more
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Engineering simulations for cancer systems biology [PDF]
Current Drug Targets, 2012 Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses.
Andrews, Paul S. +8 more
core +7 more sources
Complexity in cancer biology: is systems biology the answer?
Cancer Medicine, 2013 Complex phenotypes emerge from the interactions of thousands of macromolecules that are organized in multimolecular complexes and interacting functional modules. In turn, modules form functional networks in health and disease.
Evangelia Koutsogiannouli +2 more
doaj +4 more sources
Systems Approaches to Cancer Biology [PDF]
Cancer Research, 2016 Abstract Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and ...
Tenley C. Archer +8 more
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Review of Computational Systems Biology of Cancer [PDF]
BioMedical Engineering OnLine, 2013 Review of "Computational Systems Biology of Cancer" by Emmanuel Barillot, Laurence Calzone, Philippe Hupe, Jean-Philippe Vert and Andrei Zinovyev, Chapman & Hall/CRC ...
Eric Bullinger, Monica Schliemann
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Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics
iScience, 2023 Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto +9 more
doaj +1 more source
A systems biology view of cancer [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009 In order to understand how a cancer cell is functionally different from a normal cell it is necessary to assess the complex network of pathways involving gene regulation, signaling, and cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy.
Vladimir Shulaev +10 more
openaire +3 more sources
Genome Biology, 2022 Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer development ...
Lisa Dressler +15 more
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Mathematical and statistical modeling in cancer systems biology. [PDF]
Front Physiol, 2012 Cancer is a major health problem with high mortality rates. In the post-genome era, investigators have access to massive amounts of rapidly accumulating high-throughput data in publicly available databases, some of which are exclusively devoted to housing Cancer data.
Blair RH, Trichler DL, Gaille DP.
europepmc +6 more sources
Pioneer factors in development and cancer
iScience, 2021 Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
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