Results 271 to 280 of about 1,632,468 (362)

Racial disparities in ovarian cancer survival transcend the somatic mutational landscape. [PDF]

Transl Cancer Res
Morgan RD, Burghel GJ.
europepmc   +1 more source

Exploring the Therapeutic Potential of Moringa oleifera Against Lung Cancer Through Network System Biology and Molecular Docking Analysis

Anuj Singh, Deepak Ohri, Olaf Wolkenhauer, Shailendra K. Gupta, Krishna P. Singh   +4 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Precision Therapeutics Through Bioactive Compounds: Metabolic Reprogramming, Omics Integration, and Drug Repurposing Strategies. [PDF]

Int J Mol Sci
Costanzo M, Roviello GN.
europepmc   +1 more source

OR04-03 Using integrative lipid systems biology to understand adrenocortical cancer [PDF]

Sheba Jarvis, Lee A. Gethings, Larry D. Reid, Mark Towers, Wiebke Arlt, Cristina L. Ronchi, Charlotte L. Bevan   +6 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

A NAMs-Based Microphysiological System for Metastasis and Mechanobiology Studies. [PDF]

Thorac Res Pract
Dogan B, Saglam-Metiner P, Goksel T, Yesil-Celiktas O.   +3 more
europepmc   +1 more source

Center of cancer systems biology second annual workshop--tumor metronomics: timing and dose level dynamics. [PDF]

Cancer Res, 2013
Hahnfeldt P, Hlatky L, Klement GL.
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source