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Systems biology and cancer [PDF]
Progress in Biophysics and Molecular Biology, 2011 The systems approach to complex biological problems has rapidly gained ground during the first decade of this century. There are several reasons for this development. An important one is that while the achievement of sequencing the complete human genome, and those of other species, has been of great benefit to fundamental science, for example in ...
Soto, A +3 more
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Engineering Simulations for Cancer Systems Biology [PDF]
Current Drug Targets, 2012 Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses. In this way, in silico models become a scientific instrument for investigation, and so should be developed to high standards, be carefully calibrated and ...
Paul S. Andrews +8 more
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A Roadmap of Cancer Systems Biology
Nature Precedings, 2010 What is cancer systems biology? Why should we conduct systems biology research in cancer? What is the relationships between systems biology and personalized medicine? How do we conduct cancer systems biology research?
E. Wang
semanticscholar +4 more sources
Systems Biology Understanding of the Effects of Lithium on Cancer [PDF]
Frontiers in Oncology, 2018 Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action.
Weihao Ge, E. Jakobsson
semanticscholar +6 more sources
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism [PDF]
Scientific Reports, 2017 Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Daniel C. Zielinski +5 more
semanticscholar +3 more sources
Complexity in cancer biology: is systems biology the answer?
Cancer Medicine, 2013 Complex phenotypes emerge from the interactions of thousands of macromolecules that are organized in multimolecular complexes and interacting functional modules. In turn, modules form functional networks in health and disease.
Evangelia Koutsogiannouli +2 more
doaj +4 more sources
Cancer Systems Biology: a peek into the future of patient care? [PDF]
Nat Rev Clin Oncol, 2014 Werner HM, Mills GB, Ram PT.
europepmc +2 more sources
Omics/systems biology and cancer cachexia.
Seminars in Cell & Developmental Biology, 2016 Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology.
I. Gallagher +4 more
semanticscholar +5 more sources
A systems biology view of cancer [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009 In order to understand how a cancer cell is functionally different from a normal cell it is necessary to assess the complex network of pathways involving gene regulation, signaling, and cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy.
Vladimir Shulaev +10 more
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