Results 21 to 30 of about 990,872 (342)

Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

Communications Biology, 2023
The discovery and characterization of antigen-specific CD8+ T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers.
William Chour, Jongchan Choi, Jingyi Xie, Mary E. Chaffee, Thomas M. Schmitt, Kathryn Finton, Diana C. DeLucia, Alexander M. Xu, Yapeng Su, Daniel G. Chen, Rongyu Zhang, Dan Yuan, Sunga Hong, Alphonsus H. C. Ng, Jonah Z. Butler, Rick A. Edmark, Lesley C. Jones, Kim M. Murray, Songming Peng, Guideng Li, Roland K. Strong, John K. Lee, Jason D. Goldman, Philip D. Greenberg, James R. Heath   +24 more
doaj   +1 more source

Systems Approaches to Cancer Biology [PDF]

Cancer Research, 2016
Abstract Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and ...
Archer, Tenley C, Fertig, Elana J, Gosline, Sara JC, Hafner, Marc, Hughes, Shannon K, Joughin, Brian A, Meyer, Aaron S, Piccolo, Stephen R, Shajahan-Haq, Ayesha N   +8 more
openaire   +4 more sources

Neural signaling modulates metabolism of gastric cancer

iScience, 2021
Summary: Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that vagotomy in the mouse ...
Hanne-Line Rabben, Gøran Troseth Andersen, Magnus Kringstad Olsen, Anders Øverby, Aleksandr Ianevski, Denis Kainov, Timothy Cragin Wang, Steinar Lundgren, Jon Erik Grønbech, Duan Chen, Chun-Mei Zhao   +10 more
doaj   +1 more source

The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

Genome Biology, 2019
The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles.
Dimitra Repana, Joel Nulsen, Lisa Dressler, Michele Bortolomeazzi, Santhilata Kuppili Venkata, Aikaterini Tourna, Anna Yakovleva, Tommaso Palmieri, Francesca D. Ciccarelli   +8 more
doaj   +1 more source

The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]

, 2018
PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core   +2 more sources

Edgetic perturbation models of human inherited disorders

Molecular Systems Biology, 2009
Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes’ and ‘edges’, respectively.
Quan Zhong, Nicolas Simonis, Qian‐Ru Li, Benoit Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, Kavitha Venkatesan, Danny Mou, Venus Swearingen, Muhammed A Yildirim, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E Hill, Michael E Cusick, Marc Vidal   +23 more
doaj   +1 more source

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]

, 2017
Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash, Corbett, Austin J, Jamshidi, Neema, Palsson, Bernhard O, Thomas, Alex, Zielinski, Daniel C   +5 more
core   +1 more source

Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm

npj Systems Biology and Applications, 2017
Personalized medicine: Signature-guided cancer therapy Personalized cancer therapy is one of the holy grails of oncology, as the ability to determine what treatment would best benefit a patient would serve not only to improve outcomes, but also mitigate ...
Daniel J. McGrail, Curtis Chun-Jen Lin, Jeannine Garnett, Qingxin Liu, Wei Mo, Hui Dai, Yiling Lu, Qinghua Yu, Zhenlin Ju, Jun Yin, Christopher P. Vellano, Bryan Hennessy, Gordon B. Mills, Shiaw-Yih Lin   +13 more
doaj   +1 more source

Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors

iScience, 2021
Summary: Genomic data can facilitate personalized treatment decisions by enabling therapeutic hypotheses in individual patients. Mutual exclusivity has been an empirically useful signal for identifying activating mutations that respond to single agent ...
Haider Inam, Ivan Sokirniy, Yiyun Rao, Anushka Shah, Farnaz Naeemikia, Edward O'Brien, Cheng Dong, David M. McCandlish, Justin R. Pritchard   +8 more
doaj   +1 more source

Cyclin-dependent kinases as drug targets for cell growth and proliferation disorders. A role for systems biology approach in drug development. Part II - CDKs as drug targets in hypertrophic cell growth. Modelling of drugs targeting CDKs [PDF]

, 2012
Cyclin-dependent kinases (CDKs) are key regulators of cell growth and proliferation. Impaired regulation of their activity leads to various diseases such as cancer and heart hypertrophy.
Idowu, Michael A.
core   +3 more sources