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Cancer systems biology: a network modeling perspective

Carcinogenesis, 2009
Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell type and tissue origin but also as a disease involving dysregulation of multiple pathways governing fundamental cell processes such as death, proliferation ...
P. Kreeger, D. Lauffenburger
semanticscholar   +3 more sources

Systems Biology of Cancer Metastasis. [PDF]

Cell Systems, 2019
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for ...
Yasir Suhail, Margo P. Cain, K. Vanaja, Paul Kurywchak, A. Levchenko, R. Kalluri, Kshitiz   +6 more
semanticscholar   +3 more sources

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling

iScience, 2021
Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha, Inês Godet, Furkan Kurtoglu, John Metzcar, Kali Konstantinopoulos, Soumitra Bhoyar, Daniele M. Gilkes, Paul Macklin   +7 more
doaj   +1 more source

Systems Approaches to Cancer Biology [PDF]

Cancer Research, 2016
Abstract Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and ...
Tenley C. Archer, Elana J. Fertig, Sara J.C. Gosline, Marc Hafner, Shannon K. Hughes, Brian A. Joughin, Aaron S. Meyer, Stephen Piccolo, Ayesha N. Shajahan‐Haq   +8 more
openalex   +5 more sources

Development of OX40 agonists for canine cancer immunotherapy

iScience, 2022
Summary: Recent breakthroughs in cancer immunotherapy have provided unprecedented clinical benefits to human cancer patients. Cancer is also one of the most common causes of death in pet dogs.
Damien Ruiz, Chloe Haynes, Jonathan Marable, Chetan Pundkar, Rebecca L. Nance, Deepa Bedi, Payal Agarwal, Amol S. Suryawanshi, Amarjit Mishra, Bruce F. Smith, Maninder Sandey   +10 more
doaj   +1 more source

A network approach reveals driver genes associated with survival of patients with triple-negative breast cancer

iScience, 2021
Summary: We aimed to identify triple-negative breast cancer (TNBC) drivers that regulate survival time as predictive signatures that improve TNBC prognostication.
Courtney D. Dill, Eric B. Dammer, Ti'ara L. Griffen, Nicholas T. Seyfried, James W. Lillard, Jr.   +4 more
doaj   +1 more source

Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

iScience, 2023
Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto, Ksenija Slavic-Obradovic, Daniela Fürweger, Barbara Thaler, Abdallah Souabni, Sebastian Carotta, Martin Aichinger, Ulrich Reiser, Maria Antonietta Impagnatiello, Iñigo Tirapu   +9 more
doaj   +1 more source

Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource

Genome Biology, 2022
Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer development ...
Lisa Dressler, Michele Bortolomeazzi, Mohamed Reda Keddar, Hrvoje Misetic, Giulia Sartini, Amelia Acha-Sagredo, Lucia Montorsi, Neshika Wijewardhane, Dimitra Repana, Joel Nulsen, Jacki Goldman, Marc Pollitt, Patrick Davis, Amy Strange, Karen Ambrose, Francesca D. Ciccarelli   +15 more
doaj   +1 more source

A systems biology view of cancer [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009
In order to understand how a cancer cell is functionally different from a normal cell it is necessary to assess the complex network of pathways involving gene regulation, signaling, and cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy.
Laubenbacher, Reinhard, Hower, Valerie, Jarrah, Abdul, Torti, Suzy V., Shulaev, Vladimir, Mendes, Pedro, Torti, Frank M., Akman, Steven   +7 more
openaire   +2 more sources

Pioneer factors in development and cancer

iScience, 2021
Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
doaj   +1 more source