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Complexity in cancer biology: is systems biology the answer?
Cancer Medicine, 2013 Complex phenotypes emerge from the interactions of thousands of macromolecules that are organized in multimolecular complexes and interacting functional modules. In turn, modules form functional networks in health and disease.
Evangelia Koutsogiannouli +2 more
doaj +4 more sources
Systems Biology Understanding of the Effects of Lithium on Cancer [PDF]
Frontiers in Oncology, 2018 Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action.
Weihao Ge, E. Jakobsson
semanticscholar +6 more sources
Systems Approaches to Cancer Biology [PDF]
Cancer Research, 2016 Abstract Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and ...
Tenley C. Archer +8 more
openalex +6 more sources
Cancer systems biology: a network modeling perspective [PDF]
Carcinogenesis, 2009 Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell type and tissue origin but also as a disease involving dysregulation of multiple pathways governing fundamental cell processes such as death, proliferation ...
P. Kreeger, D. Lauffenburger
semanticscholar +6 more sources
Review of Computational Systems Biology of Cancer [PDF]
BioMedical Engineering OnLine, 2013 Review of "Computational Systems Biology of Cancer" by Emmanuel Barillot, Laurence Calzone, Philippe Hupe, Jean-Philippe Vert and Andrei Zinovyev, Chapman & Hall/CRC ...
Eric Bullinger, Monica Schliemann
openalex +3 more sources
Systems Biology of Cancer Metastasis. [PDF]
Cell Systems, 2019 Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for ...
Yasir Suhail +6 more
semanticscholar +4 more sources
Identification of hub pathways and drug candidates in gastric cancer through systems biology
Scientific Reports, 2022 Gastric cancer is the fourth cause of cancer death globally, and gastric adenocarcinoma is its most common type. Efforts for the treatment of gastric cancer have increased its median survival rate by only seven months.
Seyed Reza Salarikia +4 more
semanticscholar +1 more source
A systems biology view of cancer [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009 In order to understand how a cancer cell is functionally different from a normal cell it is necessary to assess the complex network of pathways involving gene regulation, signaling, and cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy.
Vladimir Shulaev +10 more
openaire +3 more sources
Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem +3 more
core +5 more sources